May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Progress Toward a Platform for Studying Neural Coding of Vision: Recordings From a Flexible, Transparent Multielectrode Array
Author Affiliations & Notes
  • D. B. Shire
    Boston VA Medical Center, Ctr for Innovative Visual Rehabilitation, Boston, Massachusetts
  • O. R. Ziv
    Boston VA Medical Center, Ctr for Innovative Visual Rehabilitation, Boston, Massachusetts
  • M. D. Gingerich
    Boston VA Medical Center, Ctr for Innovative Visual Rehabilitation, Boston, Massachusetts
  • R. Jensen
    Boston VA Medical Center, Ctr for Innovative Visual Rehabilitation, Boston, Massachusetts
  • J. F. Rizzo
    Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
  • S. F. Cogan
    EIC Laboratories, Inc., Norwood, Massachusetts
  • J. L. Wyatt
    Electrical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • Footnotes
    Commercial Relationships D.B. Shire, Massachusetts Eye and Ear Infirmary, P; O.R. Ziv, None; M.D. Gingerich, None; R. Jensen, None; J.F. Rizzo, Massachusetts Eye and Ear Infirmary, P; S.F. Cogan, None; J.L. Wyatt, Massachusetts Institute of Technology, P.
  • Footnotes
    Support NSF IIS-0515134, CNF Facility; VA CIVR, NIH EY016674 HIGHWIRE EXLINK_ID="48:5:658:1" VALUE="EY016674" TYPEGUESS="GEN" /HIGHWIRE -01
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 658. doi:
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      D. B. Shire, O. R. Ziv, M. D. Gingerich, R. Jensen, J. F. Rizzo, S. F. Cogan, J. L. Wyatt; Progress Toward a Platform for Studying Neural Coding of Vision: Recordings From a Flexible, Transparent Multielectrode Array. Invest. Ophthalmol. Vis. Sci. 2007;48(13):658.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

This work is related to the efforts of the Boston Retinal Implant Project to develop a sub-retinal prosthesis to restore vision to the blind. The specific purpose of this presentation is to develop and characterize a flexible recording electrode array capable of transmitting a substantial fraction of incident light energy. This array has been used for acute in vitro experiments, and will be used chronically as part of a telemetry system reporting retinal ganglion cell output in free-roaming animal studies.

 
Methods:
 

A polyimide microfabrication process was used to create a flexible, freestanding array matrix within which indium tin oxide (ITO) electrodes were embedded. Patterning was performed by forming a sacrificial amorphous carbon layer on top of the ITO film, creating the array structure photolithographically, etching the carbon mask layer, and then transferring this pattern into the underlying ITO by Ar ion milling at 500V DC bias. The recording array has folding umbrella-like sections and a central retinal tack hole.

 
Results:
 

Substantially transparent ITO conductors have been formed into 420-electrode, 9 mm diameter flexible prototype recording arrays for acute studies (see Figure; 16 sites were connected in this design) and for future chronic epiretinal placement. The device is intended to be used for recording in awake animals in conjunction with a subretinal stimulating electrode array to study the correlation between artificial percepts resulting from coded electrical stimuli, and those arising from naturally occurring visual inputs.

 
Conclusions:
 

Part of a flexible platform for studying the neural code for vision has been developed in the form of a flexible, mostly transparent epiretinal recording electrode array that subtends a substantial visual angle. The arrays have been used for in vitro experiments, and will potentially be used in free-roaming animal studies.  

 
Keywords: age-related macular degeneration • retinal degenerations: hereditary • electrophysiology: non-clinical 
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