May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
A Case of Endogenous Fungal Endophthalmitis Caused by Paecilomyces Lilacinus in a Patient With No Other Clinical Signs of Infection
Author Affiliations & Notes
  • R. Bloom
    Ophthalmology, Albert Einstein College of Medicine/Montefiore Medical Center Department of Ophthalmology, New York, New York
  • M. Szlechter
    Ophthalmology, Albert Einstein College of Medicine/Montefiore Medical Center Department of Ophthalmology, New York, New York
  • U. Mian
    Ophthalmology, Albert Einstein College of Medicine/Montefiore Medical Center Department of Ophthalmology, New York, New York
  • M. Levi
    Ophthalmology, Albert Einstein College of Medicine/Montefiore Medical Center Department of Ophthalmology, New York, New York
  • H. Engel
    Ophthalmology, Albert Einstein College of Medicine/Montefiore Medical Center Department of Ophthalmology, New York, New York
  • Footnotes
    Commercial Relationships R. Bloom, None; M. Szlechter, None; U. Mian, None; M. Levi, None; H. Engel, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 688. doi:
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    • Get Citation

      R. Bloom, M. Szlechter, U. Mian, M. Levi, H. Engel; A Case of Endogenous Fungal Endophthalmitis Caused by Paecilomyces Lilacinus in a Patient With No Other Clinical Signs of Infection. Invest. Ophthalmol. Vis. Sci. 2007;48(13):688.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: The purpose of this case report is three-fold: 1) to report the first known case of endogenous fungal endophthalmitis caused by Paecilomyces lilacinus; 2) to highlight the efficacy of intravitreal voriconazole in the treatment of Paecilomyces; and 3) to emphasize the role of genetic PCR in the management of fungal endophthalmitis.

Methods:: Retrospective case report.

Results:: A 48-year-old patient with HIV, on Highly Active Anti-Retroviral Therapy (HAART), presented with fungal endophthalmitis. The patient had no history of ocular trauma or surgery and had no clinical signs of extraocular infection. The identity of the fungus was determined using genetic PCR and was identified as Paecilomyces lilacinus. The infection was successfully treated with intravitreal voriconazole.

Conclusions:: Although not previously described, endogenous fungal endophthalmitis may develop without systemic or extraocular signs of infection. Intravitreal voriconazole may be the most efficacious treatment for fungal endophthalmitis. Genetic PCR testing is an invaluable tool for identifying fungi, but is not commonly employed. Based on our experience, genetic PCR testing is a useful adjunct in management of fungal endophthalmitis.

Keywords: endophthalmitis • fungal disease • retinal detachment 
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