May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Comparative Antimicrobial in vitro Study of Ethly-Cyanoacrylate and 2-Octyl-Cyanoacrylate For Microorganism Related to Corneal Infection
Author Affiliations & Notes
  • J. Sanchez
    Ophthalmology, Santa Casa de Sao Paulo, Sao Paulo, Brazil
  • R. Holzchuh
    Ophthalmology, Santa Casa de Sao Paulo, Sao Paulo, Brazil
  • M. S. Murca
    Ophthalmology, Santa Casa de Sao Paulo, Sao Paulo, Brazil
  • A. Navarini
    Ophthalmology, Santa Casa de Sao Paulo, Sao Paulo, Brazil
  • L. M. J. Mimica
    Ophthalmology, Santa Casa de Sao Paulo, Sao Paulo, Brazil
  • I. L. Romero
    Ophthalmology, Santa Casa de Sao Paulo, Sao Paulo, Brazil
  • T. P. Paiato
    Ophthalmology, Santa Casa de Sao Paulo, Sao Paulo, Brazil
  • R. Y. Hida
    Ophthalmology, Santa Casa de Sao Paulo, Sao Paulo, Brazil
    Ophthalmology, Universidade de Sao Paulo, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships J. Sanchez, None; R. Holzchuh, None; M.S. Murca, None; A. Navarini, None; L.M.J. Mimica, None; I.L. Romero, None; T.P. Paiato, None; R.Y. Hida, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 742. doi:
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      J. Sanchez, R. Holzchuh, M. S. Murca, A. Navarini, L. M. J. Mimica, I. L. Romero, T. P. Paiato, R. Y. Hida; Comparative Antimicrobial in vitro Study of Ethly-Cyanoacrylate and 2-Octyl-Cyanoacrylate For Microorganism Related to Corneal Infection. Invest. Ophthalmol. Vis. Sci. 2007;48(13):742.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To compare the antimicrobial effect of ethyl-cyanoacrylate (Superbonder®, Loctite®, Brasil) and 2-octyl-cyanoacrylate (Dermabond®, Ethicon®, Johnson and Johnson®, USA)

Methods:: Microorganism related to corneal infection were studied: Pseudomonas aeruginosa (ATCC27853), Klebsiella pneumoniae (ATCC13883), Escherichia coli (ATCC25922) and Staphylococcus aureus (ATCC25923). Müeller-Hinton media were used for every microorganism. For each microorganism, 20 blank sterile 6mm disk containing 10 µl of ethyl-cyanoacrylate and 20 blank sterile 6mm disk containing 10 µl of 2-octyl-cyanoacrylate were studied. After 24 hours, all inhibition halos were measured in milimeters. After 48 hours, all samples were re-cultured to analyze its bactericidal effect.

Results:: Inhibition halo were observed in both adhesives for Staphylococcus aureus. Inhibition halo were observed only in ethyl-cyanoacrylate for Klebsiella pneumoniae and Escherichia coli. No inhibition halo were observed for Pseudomonas aeruginosa for all samples studied. Ethyl-cyanoacrylate showed a greater mean inhibition halo diameter when compared to octyl-cyanoacrylate. No bactericidal effect was observed for all the microorganism studied.

Conclusions:: Ethyl-cyanoacrylate showed to have an influence on the bacteriostatic effect for Escherichia coli and Klebsiella pneumoniae. Octyl-cyanoacrylate showed to have less influence in the bacteriostatic effect for Staphylococcus aureus when compared to ethyl-cyanoacrylate.

Keywords: cornea: basic science • microbial pathogenesis: experimental studies 
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