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J. Sanchez, R. Holzchuh, M. S. Murca, A. Navarini, L. M. J. Mimica, I. L. Romero, T. P. Paiato, R. Y. Hida; Comparative Antimicrobial in vitro Study of Ethly-Cyanoacrylate and 2-Octyl-Cyanoacrylate For Microorganism Related to Corneal Infection. Invest. Ophthalmol. Vis. Sci. 2007;48(13):742.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the antimicrobial effect of ethyl-cyanoacrylate (Superbonder®, Loctite®, Brasil) and 2-octyl-cyanoacrylate (Dermabond®, Ethicon®, Johnson and Johnson®, USA)
Microorganism related to corneal infection were studied: Pseudomonas aeruginosa (ATCC27853), Klebsiella pneumoniae (ATCC13883), Escherichia coli (ATCC25922) and Staphylococcus aureus (ATCC25923). Müeller-Hinton media were used for every microorganism. For each microorganism, 20 blank sterile 6mm disk containing 10 µl of ethyl-cyanoacrylate and 20 blank sterile 6mm disk containing 10 µl of 2-octyl-cyanoacrylate were studied. After 24 hours, all inhibition halos were measured in milimeters. After 48 hours, all samples were re-cultured to analyze its bactericidal effect.
Inhibition halo were observed in both adhesives for Staphylococcus aureus. Inhibition halo were observed only in ethyl-cyanoacrylate for Klebsiella pneumoniae and Escherichia coli. No inhibition halo were observed for Pseudomonas aeruginosa for all samples studied. Ethyl-cyanoacrylate showed a greater mean inhibition halo diameter when compared to octyl-cyanoacrylate. No bactericidal effect was observed for all the microorganism studied.
Ethyl-cyanoacrylate showed to have an influence on the bacteriostatic effect for Escherichia coli and Klebsiella pneumoniae. Octyl-cyanoacrylate showed to have less influence in the bacteriostatic effect for Staphylococcus aureus when compared to ethyl-cyanoacrylate.
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