May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Risk Factors for Developing Avascular Bleb After Fornix Based Conjunctival Flap in Trabeculectomy With Mitomycin C
Author Affiliations & Notes
  • M. Mizote
    Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan
  • K. Hirooka
    Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan
  • T. Baba
    Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan
  • M. Takagishi
    Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan
  • F. Shiraga
    Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan
  • Footnotes
    Commercial Relationships M. Mizote, None; K. Hirooka, None; T. Baba, None; M. Takagishi, None; F. Shiraga, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 829. doi:
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      M. Mizote, K. Hirooka, T. Baba, M. Takagishi, F. Shiraga; Risk Factors for Developing Avascular Bleb After Fornix Based Conjunctival Flap in Trabeculectomy With Mitomycin C. Invest. Ophthalmol. Vis. Sci. 2007;48(13):829.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To investigate risk factors for development of an avascular bleb after primary trabeculectomy with a fornix based conjunctival flap and mitomycin C (MMC).

Methods:: One year observational case series. Sixty nine eyes of 62 consecutive patients who underwent primary trabeculectomy with MMC and a fornix based conjunctival flap. The surgical success was defined by the following criteria: (A) intraocular pressure (IOP) ≤ 18 mmHg and IOP reduction ≥ 20%; and (B) IOP ≤ 15 mmHg and IOP reduction ≥ 25%. A multiple logistic regression test was used to identify risk factors for development of avascular blebs. Success rates were analyzed using Kaplan-Meier survival curves.

Results:: In 22 of 69 eyes (32%), avascular blebs developed after trabeculectomy. The risk factors for development of avascular blebs were no performance of laser suture lysis after trabeculectomy (odds ratio = 3.663, P = 0.04) and no combined cataract surgery (odds ratio = 4.564, P = 0.02). The success rates were 95%, and 91% in avascular blebs for criteria A, and B, respectively; and 89%, and 89% in vascular blebs for these criteria, respectively.

Conclusions:: No performance of laser suture lysis after trabeculectomy and no combined cataract surgery were associated with a higher risk of development of avascular blebs.

Keywords: clinical (human) or epidemiologic studies: risk factor assessment • intraocular pressure 
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