May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Assessment of mfERG, Spatial Contrast Sensitivity and Visual Field in Patients with Multiple Sclerosis
Author Affiliations & Notes
  • A. d. Moura
    University of Sao Paulo, Sao Paulo, Brazil
    Psicologia Experimental,
  • R. A. A. Teixeira
    University of Sao Paulo, Sao Paulo, Brazil
    Psicologia Experimental,
  • M. F. Costa
    University of Sao Paulo, Sao Paulo, Brazil
    Psicologia Experimental,
  • M. S. T. Barboni
    University of Sao Paulo, Sao Paulo, Brazil
    Psicologia Experimental,
  • D. Callegaro
    University of Sao Paulo, Sao Paulo, Brazil
    Neurologia,
  • D. F. Ventura
    University of Sao Paulo, Sao Paulo, Brazil
    Psicologia Experimental,
  • Footnotes
    Commercial Relationships A.D. Moura, None; R.A.A. Teixeira, None; M.F. Costa, None; M.S.T. Barboni, None; D. Callegaro, None; D.F. Ventura, None.
  • Footnotes
    Support FAPESP, CAPES/PROCAD, CNPq
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 910. doi:
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      A. d. Moura, R. A. A. Teixeira, M. F. Costa, M. S. T. Barboni, D. Callegaro, D. F. Ventura; Assessment of mfERG, Spatial Contrast Sensitivity and Visual Field in Patients with Multiple Sclerosis. Invest. Ophthalmol. Vis. Sci. 2007;48(13):910.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To assess spatial contrast sensitivity function (sCSF), visual field and multifocal ERG, in patients with multiple sclerosis, with or without history of optic neuritis.

Methods:: We evaluated twenty five patients (17F; 8M; mean age = 34.8±10.34 years) with diagnosis of multiple sclerosis. All patients had visual acuity between 0 and 0.1 logMAR and presented no alterations in a complete ophthalmologic exam. Visual field was tested with a Humphrey Campimeter, SITA algorithm, central 30-2 strategy, in Standard Automated Perimetry (SAP). sCSF was assessed with the PSYCHO software (Cambridge Research Systems). The sCSF thresholds were measured in 15 patients, at 0.2, 0.5, 1.0, 1.9, 5.3, 9.7 and 19.4 cpd. mfERGs were recorded in 12 patients using the VERIS System, with 103 hexagons and dilated pupil. The analysis was based on average of response amplitude and latency at six eccentricity rings from the fovea to 25o.

Results:: All patients showed decrease in sCSF, when compared to the control group, at all spatial frequencies (P < 0.001). The mfERG responses of ME patients were smaller in amplitude and delayed in latency, relative to the control group, at all rings, but with no statistic significance (p > 0.05). Visual field results showed a reduction in sensitivity in the ME patients, compared to the control group, but with no statistic difference (p > 0.05). There was no difference between patients with or without optic neuritis history and the results.

Conclusions:: Smaller and delayed mfERG responses, compared to controls, were found in multiple sclerosis patients with no impairment in visual acuity. The patients also showed significantly reduced sensitivity to spatial contrast and mild losses of visual field sensitivity. These results suggest that patients with diagnosis of ME and normal visual acuity may present damage in several visual functions and in retinal function, which may be related to anterograde damage in the visual pathway caused by neuronal demyelinization.

Keywords: visual impairment: neuro-ophthalmological disease • electrophysiology: clinical • contrast sensitivity 
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