May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
The Effect of Etanercept on Rabbit Electroretinogram
Author Affiliations & Notes
  • F. C. Gundogan
    Ophthalmology, Gulhane Military Medical Academy, Ankara, Turkey
  • U. Erdem
    Ophthalmology, Gulhane Military Medical Academy, Ankara, Turkey
  • G. Sobaci
    Ophthalmology, Gulhane Military Medical Academy, Ankara, Turkey
  • S. Memisoglu
    Ophthalmology, Gulhane Military Medical Academy, Ankara, Turkey
  • Y. Uysal
    Ophthalmology, Gulhane Military Medical Academy, Ankara, Turkey
  • A. Bayer
    Ophthalmology, Gulhane Military Medical Academy, Ankara, Turkey
  • Footnotes
    Commercial Relationships F.C. Gundogan, None; U. Erdem, None; G. Sobaci, None; S. Memisoglu, None; Y. Uysal, None; A. Bayer, None.
  • Footnotes
    Support Gulhane Military Medical Academy
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1290. doi:
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    • Get Citation

      F. C. Gundogan, U. Erdem, G. Sobaci, S. Memisoglu, Y. Uysal, A. Bayer; The Effect of Etanercept on Rabbit Electroretinogram. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1290.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To investigate the effect of etanercept, a potentially therapoetic agent for inflammatory eye diseases, on full-field rabbit electroretinogram (ERG).

Methods:: One eye of 5 rabbits were given 250 microgram and one eye of 5 rabbits were given 500 microgram etarnecept in 0.1 ml solution intravitreally. Balanced saline solution was injected to the fellow eyes. DTL fiber electrodes were used for active electrodes. ERGs were recorded with Roland-Consult RetiPORT system (Wiesbaden-Germany) before injections (BI), 3 days (3D) , 2 weeks (2W) and 4 weeks (4W) after the injections. The significances were investigated between the pre-injection (BI) and post-injection (3D, 2W, 4W) comparisons.

Results:: Neither scotopic nor photopic ERG components revealed retinal toxicity. There was no sigificant difference between the a- and b- wave amplitudes and implicite times between pre-injection and post-injection comparisons (BI-3D, BI-2W, BI-4W, p>0.05). There was also no significant difference for oscillatory potential parameters.

Conclusions:: In accordance with the published studies in the literature, this electrophysiological study shows the safety of intravitreally administered etanercept on retinal function.

Clinical Trial:: GMMA supported study

Keywords: electroretinography: clinical • retina 
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