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O. Alvarez-Verduzco, M. Torres-Soriano, E. Reyna-Castelan, M. Hernandez-Rojas, J. L. Díaz-Rubio, G. García-Aguirre, J. L. Guerrero-Naranjo, J. M. Jiménez-Sierra, H. Quiroz-Mercado; Tractional Retinal Detachment After Intravitreal Injection of Bevacizumab in Proliferative Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1412.
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To asses the incidence of tractional retinal detachment (TRD) induced by a single dose of intravitreal bevacizumab in patients with proliferative diabetic retinopathy (PDR).
Retrospective review of 343 patients with PDR who where treated with intravitreal injection of bevacizumab (2.5mg/0.1ml).
Five patients (1.45%) presented tractional retinal detachment 1 to 6 weeks (mean 3 weeks) after intravitreal injection. All cases underwent pars plana vitrectomy, removal of all epiretinal fibrovascular membranes, further endolaser panretinal photocoagulation and silicone tamponade.
Tractional retinal detachment may occur in a short time post intravitreal injection of bevacizumab in patients with proliferative diabetic retinopathy with extense areas of ischemia and fibrovascular proliferations, and may require prompt vitreoretinal surgery.
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