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J. Jarzabek, S. Pilli, D. Mathapati, E. Pringle, G. Menon; Role of Timing for Intravitreal Triamcinolone Injection Following PDT for Classic Subfoveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1446.
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To evaluate the efficacy of photodynamic therapy (PDT) with verteporfin combined with intravitreal triamcinolone (IVTA) injection given at two different time intervals in subfoveal classic choroidal neovascularization(CNV) secondary to age-related macular degeneration.
20 eyes were retrospectively analysed, 10 eyes received IVTA at 2 hours following PDT and 10 eyes received IVTA at 16 to 18 hours following PDT. All of them had received 4mg/0.1 ml of intravitreal triamcinolone. They were evaluated at 1week, 1month and 3 monthly intervals with slit-lamp biomicroscopy, fundus fluorescein angiography (FFA) and optical coherence tomography (OCT). Mean follow-up period was 6 months.
All eyes maintained baseline visual acuity in both groups. At 1 week interval, the difference in mean reduction in central macular thickness(CMT) was statistically sigmificant (p<0.05), the group that had IVTA at 16-18 hours did better than the group that had IVTA at <2 hours interval. At 1 month, the mean reduction of CMT was similar in both groups and this trend continued at 3 monthly follow-ups for one year. Increase in IOP was noted in 4 eyes and was well controlled with topical medication. There were no significant lens changes in phakic eyes.
Although reduction in CMT was better when IVTA was given at 16-18 hours interval than compared to 2hours interval following PDT when evaluated at 1 wk follow-up, this trend did not persist at 3 monthly follow-ups.
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