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J. Yang, S. Park, M. Kang, H. Kim, I. Chung, H. Lee; Helicobacter Pylori Infection in Conjunctival MALT Lymphoma. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1583.
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Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue(MALT lymphoma) is an extranodal lymphoma comprising morphologically heterogeneous small B-cells including centrocyte-like cells, monocytoid cells, small lymphocytes, and scattered immunoblast and centroblast-like cells. It is associated with exaggerated clonal expansion of B cells, which implicate a pathological proliferative response to antigen including bacteria. Helicobactor pylori is one of the causative agents of gastric MALT lymphoma, but it has rarely reported in extra gastric lesions.
The hematoxylin-eosion stained slides were reviewed and one paraffin block per case was selected for molecular detection of H. pylori gene.We examined H. pylori infection in fifteen cases of conjunctival MALT lymphoma, four cases of melanocytic nevus and eight normal conjunctiva. PCR amplification using DNA samples extracted from the paraffin blocks was done for H. pylori 16S rRNA gene and Vac A s/m gene.
H. pylori DNA was detected in all of conjunctival MALT lymphoma and two of four cases of melanocytic nevus. Normal conjunctival tissues didn’t reveal H. pylori DNA. 13 cases of 15 MALT lymphoma express Vac A s2 gene. 2 of 15 MALT lymphoma express Vac A m2 gene. 2 cases of 2 melanocytic nevus express Vac A s2 /m2 gene.
These results suggest that H. pylori may play a role in pathogenesis of the conjunctival MALT lymphoma H. pylori eradication therapy may be helpful in the prevention or treatment of conjunctival MALT lymphoma
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