May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Inhibition of Corneal Angiogenesis by 11-Deoxycortisol and Aldosterone
Author Affiliations & Notes
  • M. Kivilcim
    Ophthalmology, University of Arizona, Tucson, Arizona
  • G. A. Peyman
    Ophthalmology, University of Arizona, Tucson, Arizona
  • R. P. A. Manzano
    Ophthalmology, University of Arizona, Tucson, Arizona
  • M. Caro Magdaleno
    Ophthalmology, H.U.Virgen del Rocio, Sevilla, Spain
  • Footnotes
    Commercial Relationships M. Kivilcim, None; G.A. Peyman, None; R.P.A. Manzano, None; M. Caro Magdaleno, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1712. doi:
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      M. Kivilcim, G. A. Peyman, R. P. A. Manzano, M. Caro Magdaleno; Inhibition of Corneal Angiogenesis by 11-Deoxycortisol and Aldosterone. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1712.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To evaluate the effect of topically administered aldosterone and 11-deoxycortisol on experimental corneal neovascularization in rats.

Methods:: Four groups of eight eyes belonging to male Long Evans rats were evaluated in this study. The corneas of all eyes were chemically cauterized using silver nitrate on an applicator stick. After cornea cauterization the eyes received one drop twice per day of the drugs. The first two groups received aldosterone drops in two different concentrations of 40mg/ml and 4mg/ml. The third group received 4mg/ml of 11-deoxycortisol and the last group received saline drops as a control. The duration of the study was seven days. All corneas were evaluated with digital photography. The percentage of corneal neovascularization was determined with the aid of computer software. After seven days the animals were sacrificed and all corneas were investigated histopathologically.

Results:: The means of percent area of corneal neovascularization in Aldosterone 40mg/ml was 38.37%± 28.22 (p= 0.004), Aldosterone 4mg/ml was 42.50%± 31.40 (p= 0.125), 11-deoxycortisol 4mg/ml was 17.75% ± 21.60 (p=0.001) and the control group was 68.87%± 4.22. Histology was consistent with our results.

Conclusions:: Our study demonstrated that topically administered 11-deoxycortisol have anti angiogenic effects, which contributed to remarkable suppression on corneal neovascularization. Aldosterone at higher concentrations (40mg/ml) showed some anti angiogenic effect. The 11-deoxycortisol may be therapeutically beneficial in treatment of corneal neovascularization as single or combined forms in clinical trials. Key Words: Aldosterone, 11-deoxycortisol, cornea neovascularization, angiogenesis.

Keywords: cornea: basic science • neovascularization • corticosteroids 
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