May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Anti-Angiogenic Activity of Homoisoflovanone as a Potential Inhibitor of Choroidal Neovascularization
Author Affiliations & Notes
  • J. Kim
    Ophthalmology-Coll of Med, Seoul National Univ Hospital, Seoul, Republic of Korea
  • Y. S. Yu
    Ophthalmology-Coll of Med, Seoul National Univ Hospital, Seoul, Republic of Korea
  • H.-J. Kwon
    Department of Biotechnology, College of Engineering, Yonsei University, Seoul, Republic of Korea
  • K.-H. Park
    Ophthalmology-Coll of Med, Bundang Seoul National Univ Hospital, Seoul, Republic of Korea
  • J. Kim
    Division of Pharmaceutical Bioscience, College of Pharmacy, Seoul National Univ, Seoul, Republic of Korea
  • K.-W. Kim
    Division of Pharmaceutical Bioscience, College of Pharmacy, Seoul National Univ, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships J. Kim, None; Y.S. Yu, None; H. Kwon, None; K. Park, None; J. Kim, None; K. Kim, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1760. doi:
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      J. Kim, Y. S. Yu, H.-J. Kwon, K.-H. Park, J. Kim, K.-W. Kim; Anti-Angiogenic Activity of Homoisoflovanone as a Potential Inhibitor of Choroidal Neovascularization. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1760.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To explore whether homoisoflovanone from cremastra appendiculata could be a potential inhibitor of choroidal neovascularization

Methods:: To determine inhibitory activity for endothelial cell proliferation of homoisoflovanone, MTT assay and trypan blue exclusion assay was performed. In vitro endothelial cell tube formation assay was done as well. In mice model of laser-induced choroidal neovascularization, with or without intravitreal homoisoflovanone, neovascularization was measured through flourescein angiography using FITC-dextran and blood vessel count in cross section.

Results:: Homoisoflovanone significantly inhibited endothelial cell proliferation and endothelial cell tube formation. Also, it strongly suppressed laser-induced choroidal neovascularization in mice without showing any toxicity in the retina.

Conclusions:: Our data suggests that homoisoflovanone effectively inhibits in vitro and in vivo angiogenesis, and could be a potential inhibitor of choroidal neovascularization.

Keywords: choroid: neovascularization • drug toxicity/drug effects • vascular cells 
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