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J. Kim, Y. S. Yu, H.-J. Kwon, K.-H. Park, J. Kim, K.-W. Kim; Anti-Angiogenic Activity of Homoisoflovanone as a Potential Inhibitor of Choroidal Neovascularization. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1760.
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© ARVO (1962-2015); The Authors (2016-present)
To explore whether homoisoflovanone from cremastra appendiculata could be a potential inhibitor of choroidal neovascularization
To determine inhibitory activity for endothelial cell proliferation of homoisoflovanone, MTT assay and trypan blue exclusion assay was performed. In vitro endothelial cell tube formation assay was done as well. In mice model of laser-induced choroidal neovascularization, with or without intravitreal homoisoflovanone, neovascularization was measured through flourescein angiography using FITC-dextran and blood vessel count in cross section.
Homoisoflovanone significantly inhibited endothelial cell proliferation and endothelial cell tube formation. Also, it strongly suppressed laser-induced choroidal neovascularization in mice without showing any toxicity in the retina.
Our data suggests that homoisoflovanone effectively inhibits in vitro and in vivo angiogenesis, and could be a potential inhibitor of choroidal neovascularization.
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