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H. H. Kim, P. E. Carvounis, R. P. A. Manzano, J. A. Fortun, B. Chan-Kai, T. A. Albini, E. R. Holz; Anatomical Outcomes Following Treatment for Retinal Pigment Epithelium Detachment Associated With Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1802.
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To report the frequency of retinal pigment epithelium tears following treatment of retinal pigment epithelium detachment (PED) associated age-related macular degeneration (ARMD) using photodynamic therapy (PDT), intravitreous triamcinolone acetonide (IVTK) or their combination (PDT+IVTK).
Retrospective, comparative review of 33 eyes of 31 consecutive patients with ARMD-associated PEDs measuring more than 2/3 disc diameters, with initial visual acuity better than 20/200, treated with one or more sessions of PDT with Verteporfin, IVTK (4mg), or PDT+IVTK.
At 12 months, PEDs persisted in 80%, 87.5% and 50% of eyes in the PDT, IVTK and PDT+IVTK group (p=0.81) with RPE tears developing in 25% of eyes in the PDT+IVTK group compared to no eyes in the PDT or IVTK groups (p=0.04).
PDT, IVTK, and PDT+IVTK are ineffective in resolving PEDs. PDT+IVTK results in a statistically significant increase in RPE tears compared to PDT or IVTK alone.
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