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M. Suzuki, T. Tanabe, S. Amano, T. Oshika; Longitudinal Study of Corneal Topography in Keratoconus Suspect. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1837.
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To compare quantitative descriptors of corneal topography between progressive and non-progressive eyes of keratoconus suspect.
Subjects were 34 eyes of 34 patients of keratoconus suspect. Keratoconus suspected eyes are defined as eyes with suspicious findings by videokeratography examinations (TMS, Tomey) but having no clinical findings (for instance Fleischer's ring or Vogt's striae) in slit-lamp biomicroscopy. Their age ranged from 13 to 40 years old (24.1 ± 7.5, mean ± SD). They were observed for 3 years or longer. The average follow-up period was 6.0 ± 2.2 years. Best corrected visual acuity, slit-lamp biomicroscopy, and videokeratography examinations were analyzed. We classified keratoconus suspected cases into two groups; progressive group which presented apparent keratoconus findings during the follow-up period, and non-progressive group which did not progress to keratoconus. Quantitative descriptors of corneal topography were compared between the two groups. Indices selected for statistical analysis were surface regularity index (SRI), surface asymmetry index (SAI), and four Fourier indices (spherical component, asymmetry, regular astigmatism, and higher order irregularity).
During the follow-up period, 5 eyes out of 34 keratoconus suspected eyes progressed to keratoconus. SAI, asymmetry, and regular astigmatism of the first visit in the progressive group were significantly larger than those in the non-progressive group (p=0.006, 0.0001, 0.002). The yearly change rates of SAI, SRI, spherical component, asymmetry, and higher order irregularity in the progressive group were significantly larger than those in the non-progressive group.
Progressive and non-progressive eyes of keratoconus suspect showed significant differences in SAI, asymmetry, and regular astigmatism at the first visit.
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