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B. J. Reiser, J. Schallhorn, M. Tang, Y. Li, D. Huang; Measuring the Anterior Corneal Vault Using the Visante Anterior Segment OCT: A Novel Diagnostic Tool for Keratoconus. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1851.
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To identify and evaluate anatomic parameters in the diagnosis of keratoconus using the Visante Anterior Segment OCT.First, a keratoconic eye may have a greater corneal vault (CV) than a normal eye due to the forward protrusion of the cornea. Second, a keratoconic eye may have a narrower anterior chamber width (ACW) since the corneal vertex tends to be more inferior when the ACW is narrower.
In a retrospective case study, 17 eyes of 10 patients diagnosed with keratoconus (the Keratoconus group) and 31 eyes of 31 patients undergoing routine cataract surgery (the Control group) were measured for ACW and CV. Statistical analysis was performed to determine any statistical significance of each parameter in the diagnosis of keratoconus.
The average ACW is 12.24 ± 0.51 mm (mean ± standard deviation) for the Keratoconus group and 11.90 ±0.46 mm for the Control group. The average CV is 3.40 ±0.37 mm (p=0.22) for the Keratoconus group and 3.02 ±0.20 mm (p=0.0001) for the Control group. Both differences are statistically significant. 95% percentile for the Keratoconus group was 3.35mm. The area under the receiver operating characteristic curve (AROC) is 0.82 ± 0.51 for CV.
CV is greater for keratoconic eyes than normal eyes while the ACW is not narrower as we postulated. Measuring the CV in patients using the Visante Anterior Segment OCT may be an effective tool in the diagnosis of keratoconus.
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