May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
The Validity of Macular Pigment Measurements Using HFP in Patients With Age-Related Macular Degeneration
Author Affiliations & Notes
  • B. R. Hammond, Jr.
    Psychology, University of Georgia, University of Georgia, Athens, Georgia
  • J. S. Stringham
    Psychology, University of Georgia, University of Georgia, Athens, Georgia
  • J. M. Nolan
    Physical and Quantitative Sciences,, Waterford Institute of Technology, Waterford, Ireland
  • B. R. Wooten
    Psychology, Brown University, Providence, Rhode Island
  • M. Snodderly
    Institute of Neuroscience, University of Texas, Austin, Texas
  • Footnotes
    Commercial Relationships B.R. Hammond, None; J.S. Stringham, None; J.M. Nolan, None; B.R. Wooten, Macular Metrics Corp., E; M. Snodderly, None.
  • Footnotes
    Support Gustavus and Louise Pfeiffer Research Foundation, and
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2135. doi:
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      B. R. Hammond, Jr., J. S. Stringham, J. M. Nolan, B. R. Wooten, M. Snodderly; The Validity of Macular Pigment Measurements Using HFP in Patients With Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2135.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To assess the validity of measuring macular pigment optical density (MP OD) in patients with early age-related macular degeneration (AMD) using heterochromatic flicker photometry (HFP). The validity criteria were based on the similarity of the spectral absorption curves to ex vivo curves of lutein and zeaxanthin and the similarity of spatial density profiles to those seen in subjects without retinal disease.

Methods:: Standard Maxwellian view optics and the macular densitometer were used to measure MP spatial density and spectral absorption curves. 34 AMD subjects with normal color vision and one protanope were tested. All subjects were characterized via clinical exams and blinded grading of color fundus photographs using the Wisconsin Age-Related Maculopathy Grading System.

Results:: Spatial density profiles were measured in 19 subjects. These profiles were highly similar to those that have been measured in subjects without retinal disease when using HFP. The shape of the spectral absorption curves for the AMD subjects corresponded well to an ex vivo template.

Conclusions:: These data support the validity of the HFP method for measuring MP density in subjects with early AMD.

Keywords: macular pigment • age-related macular degeneration • clinical research methodology 
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