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S. P. Rothenbuehler, S. Wolf, E. Weyermann, N. Roeoesli, B. Frueh, S. Griesser, D. Goldblum, U. Wolf-Schnurrbusch; Contrast Sensitivity, Color Perception and Macular Pigment in Patients With Age-Related Maculopathy and Blue Light-Filtering Intraocular Lens. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2151.
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To compare postoperative visual acuity (VA), contrast sensitivity, color perception, and Macular Pigment Density (MPD) in patients with early age-related Maculopathy (ARM) after implantation of blue light-filtering AcrySof® Natural (SN60AT) or AcrySof® single-piece (SA60AT) intraocular lenses (IOLs).
Inclusion criteria were an age above 50 years, early stage ARM (Rotterdam Classification, stages 1a to 3), willingness and possibility for examination 3 month postoperatively. Stage of ARM was classified by color fundus photos according to the Rotterdam Classification. All patients underwent best corrected distance VA (ETDRS), contrast sensitivity (Pelly-Robson chart), color perception (desaturated Farnsworth-Munsell Dichotomous D-15 Test), MPD measurements with a modified confocal scanning laser ophthalmoscope following a standard operation procedure. MPD maps were calculated from autofluorescence images recorded at 488nm and 514nm. MPD was quantified from MPD maps within 0.5 degree around the centre of the fovea.
We included in total 93 patients (41 male, 52 female) aged from 57 to 71 years (mean: 69.8 ± 5.6) into this prospective, randomized study. Forty-two (45.2%) patients with SN60AT and 51 (54.8%) patients with SA60AT IOL. Best corrected VA 3 month postoperatively was 20/20 or better in 95.2% of SN60AT eyes am 94.6% in SA60AT eyes. There were no statistically significant differences in contrast sensitivity scores or color perception. Mean MPD was 0.36 ± 0.21 density units (D.U.). There were no statistically significant differences in MPD values (SN60AT: 0.37 ± 0.23 D.U. vs. SA60AT: 0.38 ± 0.20 D.U.).
The blue light-filtering AcrySof® Natural (SN60AT) IOL has postoperative comparable results with AcrySof® single-piece (SA60AT) IOL. A possible protective effect of blue light-filtering IOL for ARM and a predictive interpretation of our results have to be investigated in further studies. We hope to improve our understanding of the predisposing factors, clinical course and prognostic factors of ARM and ARMD.
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