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S. Ishiko, Y. Kato, E. Sato, H. Kagokawa, J. Takahashi, A. Yoshida; Simultaneous Examination of SLO/OCT/ICG and Microperimetric Findings in Eyes With Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2158.
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To study the relationship between structural and angiographic changes and functional disturbances in eyes with age-related macular degeneration (AMD) using 3D-OCT (optical coherence tomography) angiography and microperimetry.
Six eyes with AMD were examined by 3D-OCT angiography with a single light source, which can perform simultaneous fundus and indocyanine green angiography (ICG) examinations using scanning laser ophthalmoscopy (SLO) and cross-sectional and transverse imaging using OCT. Retinal sensitivity was evaluated using microperimetry.
An accurate comparison of the locations of pathologies on the SLO image, transversal image, and ICG image was possible using 3D-OCT angiography. In the ICG image overlaying the transversal image, it was easy to observe the extent and depth of choroidal neovascularization. These images could be easily compared to the microperimetric findings. Although there were scotomatous areas related to the pathologic changes, some areas were unrelated to the pathology.
3D-OCT angiography facilitated observation not only of detailed 3D structural changes but also the accurate location of the pathology related to the neovascularization. To evaluate these findings with functional findings using microperimetry, it would be useful to understand the detailed pathology and evaluate the effectiveness of treatment in eyes with AMD.
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