May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Spectral Domain Optical Coherence Tomography on Optic Nerve Head Drusen
Author Affiliations & Notes
  • K. Yi
    Department of Ophthalmology, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts
  • M. Mujat
    Department of Dermatology, Massachusetts General Hospital, Wellman Center for Photomedicine, Harvard Medical School, Boston, Massachusetts
  • B. H. Park
    Department of Dermatology, Massachusetts General Hospital, Wellman Center for Photomedicine, Harvard Medical School, Boston, Massachusetts
  • W. Sun
    Department of Dermatology, Massachusetts General Hospital, Wellman Center for Photomedicine, Harvard Medical School, Boston, Massachusetts
    Department of Physics, Boston University, Boston, Massachusetts
  • J. F. de Boer
    Department of Dermatology, Massachusetts General Hospital, Wellman Center for Photomedicine, Harvard Medical School, Boston, Massachusetts
  • T. C. Chen
    Department of Ophthalmology, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts
  • Footnotes
    Commercial Relationships K. Yi, None; M. Mujat, patent application, P; B.H. Park, patent application, P; W. Sun, None; J.F. de Boer, sponsored by Nidek, F; patent application, P; T.C. Chen, None.
  • Footnotes
    Support NIH Grant 1 RO1EY014975-01
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2477. doi:
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    • Get Citation

      K. Yi, M. Mujat, B. H. Park, W. Sun, J. F. de Boer, T. C. Chen; Spectral Domain Optical Coherence Tomography on Optic Nerve Head Drusen. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2477.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To demonstrate spectral domain optical coherence tomography (SDOCT) images in eyes with optic nerve head drusen (ONHD) and compare the findings of other diagnostic technologies as well as the histologic findings.

 
Methods:
 

Setting: Massachusetts Eye and Ear Infirmary patients with bilateral ONHD.

 
Results:
 

SDOCT can demonstrate histology-relevant two-dimensional images as well as 3-dimensional videos of the ONHD. Signal-poor region with high signaled borders were the findings of ONHD.Figure 1. Histologic finding (X50, top, left, X100, top, right, Toluidine blue staining) and the several serial images of SDOCT of the patient with optic nerve head drusen (ONHD) who was exenterated due to the right orbital malignant melanoma. Most of the calcific substance was lost, too. Multilobulated large ONHD and small ONHD above the lamina cribrosa were shown on the nasal side of optic nerve head. The second rows of SDOCT images were redisplayed (blue boxes) and marked for better visualization of the original images. The SDOCT shows signal-poor region (asterisk) with relatively high signaled delineated borders of presumed drusen (thin arrows).

 
Conclusions:
 

The ultra-high speed ultra-high resolution images acquired by SDOCT may improve our ability to diagnose and manage ONHD.  

 
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • optic disc • drusen 
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