May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
High-Speed, High-Resolution Spectral Domain OCT Improves Imaging, Localization, and Quantification of Macular Pathology in AMD
Author Affiliations & Notes
  • R. M. Awdeh
    Duke University, Durham, North Carolina
    Ophthalmology,
  • A. Koreishi
    Duke University, Durham, North Carolina
    Ophthalmology,
  • E. Davies
    Duke University, Durham, North Carolina
    Ophthalmology,
  • M. Stopa
    Duke University, Durham, North Carolina
    Ophthalmology,
  • B. Bower
    Duke University, Durham, North Carolina
    Biomedical Engineering,
  • J. A. Izatt
    Duke University, Durham, North Carolina
    Biomedical Engineering,
  • C. Toth
    Duke University, Durham, North Carolina
    Ophthalmology, Biomedical Engineering,
  • Footnotes
    Commercial Relationships R.M. Awdeh, None; A. Koreishi, None; E. Davies, None; M. Stopa, Patent, P; B. Bower, Bioptogen, E; Patent, P; J.A. Izatt, Bioptogen, I; Patent, P; C. Toth, Patent, P; Genentech (research support); Alcon (patent royalties), F.
  • Footnotes
    Support Grant 1R21-EY-017393-01
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2600. doi:
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      R. M. Awdeh, A. Koreishi, E. Davies, M. Stopa, B. Bower, J. A. Izatt, C. Toth; High-Speed, High-Resolution Spectral Domain OCT Improves Imaging, Localization, and Quantification of Macular Pathology in AMD. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2600.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: Compare retinal pathology images determined from three-dimensional high-speed, high resolution spectral domain optical coherence tomography (SDOCT) to that of conventional optical coherence tomography in patients with age-related macular degeneration (AMD).

Methods:: Forty nine eyes of 28 eligible patients had both conventional and spectral domain OCT imaging. The superluminescent diode source for SDOCT was at 840 nm (Δ = 49 nm, coherence length in tissue 4.7µm). A 3D block of 100 retinal scans was acquired in 5.7 seconds. SDOCT images were captured at a rate of 20,000 A-scans per second. Images were interpreted for several criteria including drusen, cystoid macular edema, subretinal fluid, pigment epithelial detachment (PED), retinal pigment epithelium atrophy, and photoreceptor layer thinning.

Results:: Critical AMD pathology not resolved on conventional imaging could be resolved with SDOCT. This included extent of disease and composition of components of disease (ie drusen and PED composition).

Conclusions:: SDOCT allows for enhanced imaging including extent of disease and composition of AMD pathology in the macula. Further, this technology allows for quantifiable monitoring of disease progression and response to therapy.

Keywords: age-related macular degeneration • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retina 
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