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A. A. Moshfeghi, C. A. Puliafito; Utility of Optos P200MA for Simultaneous Fluorescein Angiographic Imaging of the Posterior Pole and Retinal Periphery in Patients With Retinovascular Disease. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2611.
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To describe the ability of the Optos P200MA prototype ultra-widefield fluorescein angiography system to evaluate patients with retinovascular disease. The widefield imaging system (200 degree retinal view) incorporates a red-green scanning laser for acquisition of "color" fundus images and a blue (488 nm) scanning laser for acquisition of fundus fluorescein angiographic images.
Single-center, retrospective, non-comparative, case-series.
One normal volunteer and 5 patients with retinovascular disease were successfully imaged with the Optos P200MA ultrawidefield fluorescein angiographic system. Diseases evaluated with prototype ultra-widefield system included: proliferative diabetic retinopathy (PDR), central retinal vein occlusion, branch/hemi retinal vein occlusion, proliferative sickle-cell retinopathy, and myopic macular degeneration with choroidal neovascularization. In addition to providing high resolution (13 microns) angiographic images of the retinal periphery showing wide-spread capillary non-perfusion in 2 patients (1 patient with proliferative sickle-cell retinopathy seen in the image below and 1 patient with PDR), the P200MA system also provided good resolution angiographic images of the macula in the normal volunteer as well as the patient with myopic choroidal neovasculization.
Our clinical experience with the Optos P200MA with fluorescein capability demonstrates that it appears to be a viable system for simultaneous angiographic imaging of the posterior pole and retinal periphery in patients with a variety of retinal vascular diseases. It appears to be particularly helpful in delineating areas of peripheral retinal non-perfusion and peripheral foci of neovascularization. Future comparative studies are planned to compare the Optos P200MA versus conventional fluorescein angiogrpahy in evaluting peripheral retinal pathology.
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