May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Near-Infrared Hyperspectral Images of Human Ocular Fundus and Their Processing With Decorrelation Stretch
Author Affiliations & Notes
  • T. Nagaoka
    Cancer Diagnostic Research Division, Shizuoka Cancer Center Research Institute, Sunto-gun, Japan
  • A. Nakamura
    Advanced Research Institute for Science and Engineering,
    Waseda University, Tokyo, Japan
  • K. Aizawa
    Advanced Research Institute for Science and Engineering,
    Waseda University, Tokyo, Japan
  • M. Kanazawa
    Department of Endocrinology, Asthma, Rheumatology and Hematology,
    Tokyo Medical University, Tokyo, Japan
  • T. Kezuka
    Department of Opthalmolgy,
    Tokyo Medical University, Tokyo, Japan
  • M. Miura
    Department of Opthalmolgy,
    Tokyo Medical University, Tokyo, Japan
  • M. Usui
    Department of Opthalmolgy,
    Tokyo Medical University, Tokyo, Japan
  • S. Ohtsubo
    Consolidated Research Institute for Advanced Science and Medical Care,
    Waseda University, Tokyo, Japan
  • T. Sota
    Department of Electrical Engineering and Bioscience,
    Waseda University, Tokyo, Japan
  • Footnotes
    Commercial Relationships T. Nagaoka, None; A. Nakamura, None; K. Aizawa, None; M. Kanazawa, None; T. Kezuka, None; M. Miura, None; M. Usui, None; S. Ohtsubo, None; T. Sota, None.
  • Footnotes
    Support The Murata Science Foundation and the Shizuoka Organization for Creation of Industries
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2752. doi:
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    • Get Citation

      T. Nagaoka, A. Nakamura, K. Aizawa, M. Kanazawa, T. Kezuka, M. Miura, M. Usui, S. Ohtsubo, T. Sota; Near-Infrared Hyperspectral Images of Human Ocular Fundus and Their Processing With Decorrelation Stretch. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2752.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: Indocyanine green fluorescence angiography (IA) makes it possible to image choroidal blood vessels. Despite the widespread acceptance of IA, its application has been restricted due to the possibility of severe complication and the discomfort of patients. The purpose of this presentation is to evaluate the potentiality of other technique to image choroidal blood vessels without contrast media.

Methods:: We customized commercialized conventional fundus camera to develop near-infrared, 720 nm < < 920 nm, hyperspectral fundus imaging apparatus. The hyperspectral image means an image each pixel of which has spectral information. As image processing, we applied decorrelation stretch to three single wavelength images with different central wavelength and the same bandwidth of 20 nm in order to separate choroidal blood vessels from other tissues.

Results:: Choroidal blood vessels were seen as bright images in single wavelength images whose central wavelength is shorter than 840 nm, while retinal blood vessels were seen as dark images in all single wavelength images under study. The decorrelation stretch could emphasize the choroidal blood vessels in the 2nd principal component image and the retinal ones in the 1st principal component image, see Fig.1.

Conclusions:: Combination of hyperspectral images with decorrelation stretch made it possible to separate the blood vessels in the choroid from the retina. Application of the proposed method to patients will be given in the presentation.

Keywords: image processing 
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