May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Preclinical Investigation of Fluorometholone Acetate as a Potential New Adjuvant During Vitreous Surgery
Author Affiliations & Notes
  • Y. Hata
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • H. Enaida
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • Y. Sassa
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • A. Ueno
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • M. Miura
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • T. Hisatomi
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • Y. Goto
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • T. Ishibashi
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • Footnotes
    Commercial Relationships Y. Hata, None; H. Enaida, None; Y. Sassa, None; A. Ueno, None; M. Miura, None; T. Hisatomi, None; Y. Goto, None; T. Ishibashi, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2895. doi:
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    • Get Citation

      Y. Hata, H. Enaida, Y. Sassa, A. Ueno, M. Miura, T. Hisatomi, Y. Goto, T. Ishibashi; Preclinical Investigation of Fluorometholone Acetate as a Potential New Adjuvant During Vitreous Surgery. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2895.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To examine the effects of intravitreal fluorometholone acetate (FMT) on the morphology and function of the retina and to investigate its possible use for vitreous surgery.

Methods:: Brown Norway rat eyes (n= 6, 12 groups) were injected with 0.05 ml of SF6 gas for vitrectomization. Four weeks later, FMT solution was injected into the vitreous cavity/subretinal space of the vitrectomized eyes at a dose of 10, 20, 40 mg/ml (0.05 ml/each eye, n=12, respectively). The retinal function was evaluated by electroretinography (ERG) at 4 and 8 weeks after FMT injection. Retinal toxicity was also assessed histologically by a light microscopy. Sham-operated eyes (0.05 ml of irrigating solution, n=12) were used as control animals. FMT-assisted pars plana vitrectomy with internal limiting membrane (ILM) peeling was performed in primate eyes (n=2). Retinal toxicity was assessed by ophthalmoscope, fluorescein angiography and electron microscopy three months after the vitreous surgery.

Results:: There was no remarkable reduction in any ERG waves at either time interval at 4 and 8 weeks after the intravitreal/subretinal injection of FMT. No obvious histological change was observed in any of the rat eyes either. Using ophthalmoscope, fluorescein angiography and electron microscopy, the appearance of the primate retinas remained to be non-pathological condition.

Conclusions:: FMT appears to be a potentially useful tool in assisting vitreous surgery including safe ILM peeling.

Keywords: drug toxicity/drug effects • vitreoretinal surgery 
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