May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Fundus Autofluorescence in Occult Macular Dystrophy
Author Affiliations & Notes
  • K. Fujinami
    Ophthalmology, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
  • G. Hanazono
    Ophthalmology, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
  • K. Tsunoda
    Ophthalmology, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
  • K. Inomata
    Ophthalmology, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Japan University School of Medicine, Tokyo, Japan
  • H. Ohde
    Ophthalmology, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Opthalmology, Keio University School of Medicine, Tokyo, Japan
  • K. Shinoda
    Ophthalmology, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Opthalmology, Keio University School of Medicine, Tokyo, Japan
  • Y. Miyake
    Ophthalmology, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
  • Footnotes
    Commercial Relationships K. Fujinami, None; G. Hanazono, None; K. Tsunoda, None; K. Inomata, None; H. Ohde, None; K. Shinoda, None; Y. Miyake, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 2902. doi:
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    • Get Citation

      K. Fujinami, G. Hanazono, K. Tsunoda, K. Inomata, H. Ohde, K. Shinoda, Y. Miyake; Fundus Autofluorescence in Occult Macular Dystrophy. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2902.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: Occult macular dystrophy (OMD) is a hereditary macular dystrophy characterized by progressively decreased visual acuity, but the fundus and fluorescein angiograms are essentially normal (Miyake Y et al , AJO 1989, 1996). Normal full-field electroretinogram (ERG) in both cone and rod components with abnormal focal macular ERG is the key to diagnose this disorder. Recently fundus autofluorescence (FAF) characteristics in patients with a wide variety of retinal diseases have been reported. By using FAF, we evaluated the macular function in patients with OMD, in comparison with those from healthy eyes.

Methods:: Five eyes of 3 patients (45 y.o. female, 66 y.o. male, 72 y.o. female) were examined. Control group consisted of 15 normal eyes of 12 patients, ranging 56 to 85 years old (mean: 70.6). FAF images were recorded by confocal scanning laser ophthalmoscopy. The argon laser (488nm) was used for excitation and a wide band-pass filter with cut-off at 500nm was incorporated in the detector. The ‘density level’ was defined as the gap between each point and the disc. Then the averaged density level in the fovea, macula, and posterior pole was calculated. We evaluated the macular function by means of the density levels in OMD, as compared with healthy eyes.

Results:: The ‘density levels’ of the three areas in OMD were within normal range, suggesting that no abnormalities were detected in FAF images recorded from eyes with OMD, in comparison with those from healthy eyes.

Conclusions:: The results indicate that RPE function evaluated by FAF in elder patients are normal, so that the disorder is limited in sensory retina. The essentially normal fundus appearance in OMD may closely be related to normal FAF images. And the density levels from FAF may have a potential to be a useful tool for ruling out other dystrophies.

Keywords: degenerations/dystrophies • electrophysiology: clinical 
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