May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Clinic vs. Reading Center Evaluation of Dense Retinal Hemorrhage at Baseline in the SCORE Branch Retinal Vein Occlusion (BRVO) Study
Author Affiliations & Notes
  • K. Warren
    Ophthalmology & Visual Sciences, FPRC, University of Wisconsin-Madison, Madison, Wisconsin
  • B. A. Blodi
    Ophthalmology & Visual Sciences, FPRC, University of Wisconsin-Madison, Madison, Wisconsin
  • M. S. Ip
    Ophthalmology & Visual Sciences, FPRC, University of Wisconsin-Madison, Madison, Wisconsin
  • I. U. Scott
    Ophthalmology, Penn State College of Medicine, Hershey, Pennsylvania
  • N. Oden
    SCORE Study Data Coordinating Center, EMMES Corporation, Rockville, Maryland
  • P. VanVeldhuisen
    SCORE Study Data Coordinating Center, EMMES Corporation, Rockville, Maryland
  • Standard Care vs Corticosteroid for Retinal Vein Occlusion Study Group
    Ophthalmology & Visual Sciences, FPRC, University of Wisconsin-Madison, Madison, Wisconsin
  • Footnotes
    Commercial Relationships K. Warren, None; B.A. Blodi, None; M.S. Ip, None; I.U. Scott, None; N. Oden, None; P. VanVeldhuisen, None.
  • Footnotes
    Support National Eye Institute (National Institutes of Health, Department of Health and Human Services) grants 5U10EY014351, 5U10EY014352, and 5U10EY014404. Investigational drug donated by Allergan, Inc.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3087. doi:
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      K. Warren, B. A. Blodi, M. S. Ip, I. U. Scott, N. Oden, P. VanVeldhuisen, Standard Care vs Corticosteroid for Retinal Vein Occlusion Study Group; Clinic vs. Reading Center Evaluation of Dense Retinal Hemorrhage at Baseline in the SCORE Branch Retinal Vein Occlusion (BRVO) Study. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3087.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To compare baseline clinic determination of presence/absence of dense macular hemorrhage (DH) in SCORE/BRVO patients to area of retinal hemorrhage as estimated by the UW Fundus Photograph Reading Center (FPRC).

 
Methods:
 

The SCORE study consists of two multicenter trials comparing safety and efficacy of preservative-free intravitreal triamcinolone acetonide injections vs. standard care for macular edema associated with branch (BRVO) and central retinal vein occlusion (CRVO). Treatment for patients assigned to standard care in the BRVO study is either immediate grid laser treatment or deferral of laser due to dense blood in the macula. We compared the ophthalmologist’s initial assessment of presence/absence of DH in 206 consecutive patients enrolled in the SCORE/BRVO study to the FPRC assessment of area of retinal hemorrhage (RH) and retinal thickening (RT). Eyes were evaluated for extent of RH and RT by imposing the ETDRS macular grid and estimating the percent of each subfield involved. Subfield results were combined by algorithm to yield overall areas of RH and RT within concentric regions.

 
Results:
 

In the SCORE/BRVO study, 140 patients without DH and 66 patients with DH were available for analysis. Patients classified by clinicians with DH were determined by FPRC to have significantly greater area of RH than those without DH. *All comparisons p<0.0002 by T-test.  

 
Conclusions:
 

In the SCORE/BRVO study to date, there is excellent association at baseline between clinician determination of presence/absence of dense macular hemorrhage and area of retinal hemorrhage as determined at the FPRC.

 
Clinical Trial:
 

www.clinicaltrials.gov NCT00105027

 
Keywords: clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • clinical (human) or epidemiologic studies: natural history 
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