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S. Kabasawa, K. Mori, I. Kawasaki, M. Oosaki, H. Iizuka, T. Awata, S. Yoneya; VEGF Polymorphisms in Japanese Patients With Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3241.
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To determine whether vascular endothelial growth factor (VEGF) gene polymorphisms are associated with age-related macular degeneration (AMD) in native, unrelated Japanese patients.
A total of 190 patients with AMD (wet AMD: 170, dry AMD: 20) and 135 control subjects without AMD were recruited for this study. The C-634G, G-1154A and C-2578A variants in the VEGF gene were assessed using a TaqMan assay. Subjects completed health and life style questionnaire including smoking, heart diseases, hypertension, and BMI.
The genotype frequency of C-2578A in the VEGF gene differed significantly between all AMD and control (p=4.25x10-3, OR(95%CI); 3.75(1.41-11.4)) and wet AMD (p=1.52x10-3, OR(95%CI); 4.73(1.78-19.4))(Fisher’s exact test, dominant model). In contrast, The VEGF C-2578A variant showed no significant association in dry AMD (p=0.74). Among health and lifestyle questionnaires, smoking is an environmental risk factor in all, wet and dry AMD (p=0.001, 0.0001, 0.02, respectively).
These data demonstrate a significant association of the VEGF polymorphism with AMD in the Japanese population, especially with the wet form of AMD.
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