May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
VEGF Polymorphisms in Japanese Patients With Age-Related Macular Degeneration
Author Affiliations & Notes
  • S. Kabasawa
    Saitama Medical University, Iruma, Japan
    Department of Ophthalmology,
  • K. Mori
    Saitama Medical University, Iruma, Japan
    Department of Ophthalmology,
  • I. Kawasaki
    Saitama Medical University, Iruma, Japan
    Department of Ophthahlmology,
  • M. Oosaki
    Saitama Medical University, Iruma, Japan
    Division of Endocrinology and Diabetes, Department of Medicine,
  • H. Iizuka
    Saitama Medical University, Iruma, Japan
    Division of RI Laboratory, Biomedical Research Center,
  • T. Awata
    Saitama Medical University, Iruma, Japan
    Division of Endocrinology and Diabetes, Department of Medicine,
    Division of RI Laboratory, Biomedical Research Center,
  • S. Yoneya
    Saitama Medical University, Iruma, Japan
    Department of Ophthahlmology,
  • Footnotes
    Commercial Relationships S. Kabasawa, None; K. Mori, None; I. Kawasaki, None; M. Oosaki, None; H. Iizuka, None; T. Awata, None; S. Yoneya, None.
  • Footnotes
    Support a grant-in-aid for scientific research (11771070) from the Ministry of Education, Culture and Science in Japan
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3241. doi:
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    • Get Citation

      S. Kabasawa, K. Mori, I. Kawasaki, M. Oosaki, H. Iizuka, T. Awata, S. Yoneya; VEGF Polymorphisms in Japanese Patients With Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3241.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To determine whether vascular endothelial growth factor (VEGF) gene polymorphisms are associated with age-related macular degeneration (AMD) in native, unrelated Japanese patients.

Methods:: A total of 190 patients with AMD (wet AMD: 170, dry AMD: 20) and 135 control subjects without AMD were recruited for this study. The C-634G, G-1154A and C-2578A variants in the VEGF gene were assessed using a TaqMan assay. Subjects completed health and life style questionnaire including smoking, heart diseases, hypertension, and BMI.

Results:: The genotype frequency of C-2578A in the VEGF gene differed significantly between all AMD and control (p=4.25x10-3, OR(95%CI); 3.75(1.41-11.4)) and wet AMD (p=1.52x10-3, OR(95%CI); 4.73(1.78-19.4))(Fisher’s exact test, dominant model). In contrast, The VEGF C-2578A variant showed no significant association in dry AMD (p=0.74). Among health and lifestyle questionnaires, smoking is an environmental risk factor in all, wet and dry AMD (p=0.001, 0.0001, 0.02, respectively).

Conclusions:: These data demonstrate a significant association of the VEGF polymorphism with AMD in the Japanese population, especially with the wet form of AMD.

Keywords: age-related macular degeneration • genetics 
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