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A. Scott, V. M. F. Owen, D. P. Crabb, N. G. Strouthidis, D. F. Garway-Heath; Predicting Progression to Glaucoma in Patients With Ocular Hypertension. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3325.
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© ARVO (1962-2015); The Authors (2016-present)
To assess the ability of the Heidelberg Retina Tomograph (HRT) Moorfields Regression Analysis (MRA) at baseline to predict glaucomatous progression of the optic disc or visual field (VF) in ocular hypertensive eyes.
198 ocular hypertensive subjects underwent regular HRT and VF testing from 1993-2001. HRT progression was assessed using the trend analysis described by Strouthidis, et al (Invest Ophthalmol Vis Sci 2006: 47; 2904-2910). VF progression was assessed by point-wise linear regression using PROGRESSOR. Subjects were classified as progressing or stable at the end of the study period. The relationship between baseline MRA classification and progression status was assessed by odds ratios (OR).
An abnormal baseline global MRA (outside normal limits + borderline) had an OR of 2.01 (95% confidence interval 0.85 - 4.83) to predict HRT progression, an OR of 1.93 (0.81 - 4.61) to predict VF progression and an OR 2.02 (95% confidence interval 1.07 - 3.81) to predict VF or HRT progression. Amongst individual disc sectors, an abnormal baseline superotemporal MRA was the best predictor of global disc progression (OR 3.05, 1.24 - 7.47). An abnormal superonasal MRA was the best predictor of global field progression (OR 1.93, 0.81 - 4.61).
An abnormal baseline Moorfields Regression Analysis is associated with two-fold risk of development of glaucoma. An abnormal superotemporal MRA sector is associated with a three-fold risk of HRT progression.
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