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S. Rho, H. Ahn, D. Shin, W. Park, K. Yoo, T. Kim; Comparison of 2-octylcyanoacrylate Adhesive and Suture Material for Eyelid Wound Closure in Rabbits. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3456.
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: To evaluate the clinical efficacy and the histopathologic tolerance of 2-octylcyanoacrylate adhesive versus suture material for eyelid wound closure in rabbits.
: We performed an experimental study on 16 eyes of eight New Zealand albino rabbits. Skin incisions of 15 mm were made 4mm apart from eyelid margin in both upper lids. The eyes of the rabbits were divided into two groups. The eyelid wound was closed by 2-octylcyanoacrylate adhesive (right eye, Group A) or by 7-0 nylon suture (left eye, Group B). The clinical efficacy of the eyelid wound closure, either with adhesives or sutures, and the clinical and histopathologic tolerance such as hyperemia, discharge, inflammatory change and fibrosis were observed at 1, 2, 4 and 8 weeks after surgery. Two rabbits were sacrificed at each of 1, 2, 4 and 8 weeks, and histopathologic examination by Hematoxylin-Eosin stain and Masson-trichrome stain was performed.
: Both eyelid wound closure methods were found to be equally efficacious and there was no significant difference in clinical efficacy between the two groups. In histopathologic examination by Hematoxylin-Eosin stain, no significant difference was found at 1 week, but, group A showed less infiltration of inflammatory cells at 2,4, and 8 weeks. In Masson-trichrome stain, we found no significant difference in degree of fibrosis.
: 2-octylcyanoacrylate adhesive was an efficient method for eyelid wound closure in rabbits. 2-octylcyanoacrylate adhesive may be a possible tissue adhesive for eyelid wound closure as well as suture materials.
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