May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Recovery of Corneal Subbasal Nerve Density After Penetrating Keratoplasty
Author Affiliations & Notes
  • J. C. Erie
    Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota
  • S. V. Patel
    Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota
  • E. J. Winter
    Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota
  • C. B. Nau
    Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota
  • J. W. McLaren
    Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota
  • W. M. Bourne
    Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota
  • Footnotes
    Commercial Relationships J.C. Erie, None; S.V. Patel, None; E.J. Winter, None; C.B. Nau, None; J.W. McLaren, None; W.M. Bourne, None.
  • Footnotes
    Support NIH Grant EY02037, Research to Prevent Blindness, Inc., Mayo Foundation
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3501. doi:
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    • Get Citation

      J. C. Erie, S. V. Patel, E. J. Winter, C. B. Nau, J. W. McLaren, W. M. Bourne; Recovery of Corneal Subbasal Nerve Density After Penetrating Keratoplasty. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3501.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To measure subbasal nerve density in clear penetrating corneal grafts and to determine the change in density with time after penetrating keratoplasty.

 
Methods:
 

Thirty clear grafts (30 patients) after penetrating keratoplasty were examined by confocal microscopy. Time after corneal transplantation varied from 2-30 years, with a uniform distribution of grafts during each consecutive 5-year interval. Subbasal nerve fiber bundles were identified in confocal images and subbasal nerve density was measured in the central cornea (visible length of nerve/frame area) and expressed as µm/mm2. Differences between nerve densities post-operatively (5-year intervals) for up to 30 years were compared to densities of 42 normal corneas by using the Wilcoxon rank-sum test (Bonferroni-adjusted for multiple comparisons).

 
Results:
 

* Rank sum test, compared to normal corneas (Bonferroni-adjusted x 6) Minimum Detectable Difference 2,836 µm/mm2 (α=0.008, ß=0.10)  

 
Conclusions:
 

Corneal subbasal nerve density after penetrating keratoplasty remains markedly decreased through 30 years compared to normal corneas.

 
Keywords: transplantation • innervation: sensation • microscopy: confocal/tunneling 
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