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A. T. Pinto, A. S. Silva, M. E. Farah, F. H. Lin, L. Isaac, R. Belfort, Jr.; Intravitreal Levels of Human Complement Factor F (CFH) in Patients With Exudative Age-Related Macular Degeneration (AMD). Invest. Ophthalmol. Vis. Sci. 2007;48(13):3601.
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Measument of vitreous and seric levels of CFH in patiens with exudative AMD.
Vitreous samples were obtained from patient with exudative AMD in the begining of a pars plana vitrectomy. Quantitative analysis of intravitreal CFH was performed by immunoradial diffusion method and enzyme-linked immunosorbent assay (ELISA). Intravitrel levels were correlated to seric levels of CFH.
Nine patients were study. Mean CFH seric levels were 709.90 Î¼g/ml (range 425.25 - 827.95). Mean intravitreal levels were 12.85 Î¼g/ml (range 2.5 - 12.0).
Intravitreal levels of CFH are 55 times lower compared to seric. We hypothesize that expression of CFH gene may be related to the low intravitreous levels of CFH.
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