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E. Perrotta, F. Montaldi, D. Domanico, S. Putano, F. Parisi, E. M. Vingolo; Multifocal Electroretinogram in Patients With Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3721.
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© ARVO (1962-2015); The Authors (2016-present)
To demonstrate clinical importance of multifocal electroretinogram (mfERG) for evaluating and monitoring the residual central retinal function in patients affected by retinitis pigmentosa.
We studied 9 patients (18 eyes) affected by primary RP mean age 38.61±15.10 years. We performed a complete ophthalmologic examination including: BCVA, indirect ophthalmoscopy evaluating degree of RPE atrophy and severity of pigmentation and visual field. Microperimetry was performed on all subjects with a recently introduced automatic fundus-related perimeter (MP1 Microperimeter; Nidek Technologies). Patients underwent multifocal electroretinogram (mfERG), new technique that allows analysis of central retinal function. Were excluded patients with BCVA lower than 20/25 and affected by other ocular systemic pathologies.
The area of reduced retinal function in the mf-ERG measurement (mean±standard deviation 91,17±45,02, 64,05±27,05, 49,06±21,50 concerning 5, 10 and 15 central degrees around the fixation target respectively) could be well correlated to the area of reduced sensitivity valuated with microperimeter (mean±standard deviation 2,64±4,13, 0,99±1,75, 2,23±2,99 concerning 5, 10 and 15 central degrees respectively). Correlation coefficient ( r ) is 0.44 concerning 5 central degrees, 0.31 concerning 10 central degrees and 0.29 concerning 15 central degrees. Data obtained by mf-ERG and microperimeter were correlated with BCVA (correlation coefficient ( r ) is 0,59 and 0,18 respectively).
Patients with RP may not always follow the typical natural course of disease. In some patients central retinal function remains quite good for several decades. According to literature data our results demonstrate a statistically significant correlation between mf-Erg data and microperimeter data in RP patients but, while microperimeter MP1 enables to evaluate retinal sensitivity recording patients' responses to different light stimuli and it offers a mean measurement of functional loss, multifocal-ERG gives an objective evaluation of electrical activity in all singular areas of the central retina and it allows to correlate structural changes with functional changes. Moreover mf-ERG responses correlate positively with BCVA values and this result demonstrates that it is better method for quantifying functional deficits and for evaluating and monitoring remaining visual function in RP patients
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