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D. Borja, A. Rosen, M. N. Hoang, A. A. Amelinckx, F. Manns, R. Augusteyn, A. Ho, J.-M. Parel; Equivalent Refractive Indices of Isolated Human and Monkey Crystalline Lenses. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3817.
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To determine if the difference in lens power between cynomolgus monkey and human lenses are due to differences in the equivalent refractive index.
Measurements were performed on 13 human (26-82 years, average =47.0±18.5 years, and <5 days postmortem) and 24 cynomolgus monkeys (45-106 months, average =74.1±25.5 months, and <1 days postmortem) isolated lenses. The lenses were carefully extracted from whole globes to avoid capsular damage and immediately immersed in room temperature DMEM. Optical power was measured using a custom designed Badal lensmeter with an aperture of 3mm. The sagittal thickness was obtained from 20X undistorted sagittal view shadowphotographs. Visibly swollen or delaminated lenses in the shadowgraph images were excluded. Central radii of curvature and asphericity of the lens’ anterior and posterior surfaces were obtained by fitting conic functions to the central 6mm zone of the anterior and posterior profiles. Ray tracing simulations of the optical power measurements incorporating the measured lens biometric properties were used to determine the central equivalent refractive index of the isolated lenses
There was no significant difference in equivalent refractive index between the two species. The higher optical power of the cynomolgus lens is due to its smaller radii of curvature.
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