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H. Mori, Y. Watanabe, M. Miura, M. Usui, T. Oshika, T. Yatagai, Y. Yasuno; Keratectomy Simulation by Three-dimensional Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3861.
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In this paper, we present a set of automated algorithms for keratectomy simulation using three dimensional optical coherence tomography.
We employed a 1310 nm wavelength swept-source optical coherence tomography (SS-OCT) with a high acquisition speed (20,000 axial scans/s) allowing three-dimensional imaging of the anterior eye segment. The SS-OCT system was capable of displaying real-time two-dimensional OCT and obtaining a three-dimensional OCT volume with the measurement time of 2 seconds. A set of algorithms of keratectomy simulation was developed for the purpose of the estimation of the effect of the phototherapeutic keratectomy (PTK) by using MATLAB software. The several corneal OCT volumes were calculated in simulations based on the parameters of the virtual PTK ablation. This study was approved by the Institutional Review Board of the University of Tsukuba and Tokyo Medical University and was in agreement the tenet of the Declaration of Helsink.
An en-face projection image of three-dimensional OCT volume of a case of granular corneal dystrophy agreed well with our visual inspection of photograph. The area of individual opacities measured by three-dimensional OCT was statistically well consistent with photograph. (Concodance correlation coefficient : 98%) For another case, the keratectomy simulations were performed with increased ablation depth of keratectomy at 50 to 120µm and an ablation pattern of 6mm Plano-ablation and 8mm transitional zone. The opacities according to virtual PTK images were decreased by around 100µm ablation. These data allowed the preoperative planning of real PTK. In real PTK for this case, the adequate ablation depth to remove sufficiently the corneal opacity was 100µm.
Keratectomy simulation that is a set of automated algorithms using SS-OCT volume allowed preoperative planning for PTK, and was helpful in deciding ablation depth of real PTK.
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