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E. Jakob, F. Mackensen, M. D. Becker; Epidemiology of Secondary Uveitis in Various Geographic Regions of the World - A Literature Analysis. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3894.
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We examined the prevalence of secondary uveitis (infection, ocular syndrome or associated systemic disease) in tertiary uveitis centers in the world literature and its distribution by geographical aspects.
All publications of the medical literature dealing with the epidemiology of uveitis were identified and filtered by predefined exclusion criteria. The papers thus obtained were subdivided into groups by geographical location of the centers and compared with each other. Special attention was paid to the distribution of primary and secondary uveitis, the rate of associated systemic disease, infection and ocular syndromes (stated in medians).
Overall 72 papers were identified in the literature and 33 papers were included in the analysis after application of the exclusion criteria. Studies with a total patient count of 22099 patients were split into the six subgroups Asia (n=5), Near East (n=4), USA (n=5), Australia (n=1) Europe I (Southern Europe) (n=4) and Europe II (Northern Western and Middle Europe) (n=10). Unfortunately, we did not find analyzable data on uveitis in South America and Africa. Europe I was the group with the smallest rate of secondary uveitis with 47% (min 38%, max 67%), whereas the Near East was the largest with 60% (50%, 70%). The rate of infections in Asia was with 24% (5%, 32%) the lowest, in Europe I with 50% (22%, 74%) the highest .The rate of uveitis with associated systemic disease was the largest in Asia with 65% (32%, 87%) and the smallest in Europe I with 37% (18%, 60%).
Especially in the diagnostics of uveitis, epidemiological data is of outstanding importance. The knowledge of preferably exact prevalence data, particularly in consideration of the geographical origin of a patient, is necessary for the calculation of a post-test-probability in laboratory tests.
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