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W. Wong, T. Wong, S.-M. Saw, P. Foster, P. Mitchell, S. Shen, S. Mya, T. Aung; Distribution and Factors Associated With Central Corneal Thickness in Malays: The Singapore Malay Eye Study (SiMES). Invest. Ophthalmol. Vis. Sci. 2007;48(13):4334.
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© ARVO (1962-2015); The Authors (2016-present)
To describe the distribution and correlation of central cornea thickness (CCT) in Malay adults in Singapore
A population-based, cross-sectional study of 3,280 (78.7% response rate) Malay persons aged 40-80 years residing in the south-western part of Singapore was conducted in 2004-6. Participants had a standardized interview, examination, ocular imaging, laboratory tests at a centralized clinic. CCT measurements were performed with an ultrasound pachymeter.
CCT was recorded for 3240 right eyes and for 3233 left eyes. CCT was normally distributed with mean of 541.3 µm (95% confidence interval [CI], 540.1 to 542.4) in right eyes and mean of 540.6 µm (95% CI, 539.4 to 541.4) in left eyes. CCT decreased with increasing age (547.7 in 40-49 years, 543.5 in 50-59 years, 540.2 in 60-69 years, and 532.3 in 70-80 years, P<0.001) but was not associated with gender. After controlling for age and gender, CCT was significantly and positive correlated with higher intraocular pressure (Pearson’s correlation coefficient 0.19, P<0.001), axial length (0.05, P=0.007), weight (0.06, P=0.001), and serum glucose (0.06, P=0.001) and glycosylated hemoglobin (0.07, P<0.001) levels. After controlling for age and gender, CCT was not associated with spherical equivalent refraction, anterior chamber depth, systolic and diastolic blood pressure and height.
In Malay adults, CCT decreased with age and was associated with higher intraocular pressure and hyperglycemia.
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