May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Pachymetry and Endothelial Cell Density After Penetrating Keratoplasty for Fuchs' Dystrophy
Author Affiliations & Notes
  • S. M. Gordon
    Cornea, Wills Eye Institute, Philadelphia, Pennsylvania
  • S. B. Hannush
    Cornea, Wills Eye Institute, Philadelphia, Pennsylvania
  • B. J. Sperling
    Cornea, Wills Eye Institute, Philadelphia, Pennsylvania
  • Footnotes
    Commercial Relationships S.M. Gordon, None; S.B. Hannush, None; B.J. Sperling, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 4693. doi:
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      S. M. Gordon, S. B. Hannush, B. J. Sperling; Pachymetry and Endothelial Cell Density After Penetrating Keratoplasty for Fuchs' Dystrophy. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4693.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To evaluate pachymetry and corneal endothelial cell density after penetrating keratoplasty (PK) for Fuchs’ dystrophy.

Methods:: 51 eyes of 41 patients with Fuchs’ dystrophy (age 52-88, mean 70) underwent PK between July 1994 and February 2005. Preoperative recipient central pachymetry and donor endothelial cell count were recorded. After mean follow up period of 63 months (range 10-137 months) central pachymetry and corneal endothelial density were documented in clear grafts.

Results:: Average pre-operative central pachymetry of native corneas was 670 microns (range 566-910). Donor endothelial cell count averaged 2845 cells/mm2 (range 2316-3976). Post-operative central pachymetry on last visit averaged 574 microns (range 436-758). Central endothelial cell density on last visit averaged 1246cells/mm2 (range 344-2820). All grafts remained clear.

Conclusions:: After PK for Fuchs’dystrophy, with a mean follow up period of 63 months, a 14% decrease in mean central pachymetry was noted. Mean central endothelial cell loss compared to preoperative donor tissue estimates was 56%. All grafts remained clear throughout the postoperative period. As the trend continues toward endothelial keratoplasty for Fuchs’ dystrophy, with its associated intra-operative trauma to the donor tissue, the importance of comparing the two different surgical techniques vis-à-vis preservation of the donor corneal endothelium cannot by underestimated.

Keywords: transplantation • cornea: endothelium • cornea: clinical science 
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