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Y. Tsuchiya, S. Kobayakawa, A. Tsuji, T. Arimura, K. Watanabe, H. Watanabe, T. Tochikubo; Comparative Efficacy of Intracameral Antibiotics versus Drug Delivery Intraocular Lens in Endophthalmitis Rabbit Model. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4740.
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To evaluate the in vivo efficacy of intracameral gatifloxacin(GFLX) 0.5% versus drug delivery intraocular lens (D.D.IOL)in the treatment of Enterococcus faecalis endophthalmitis inrabbits.
Experimental endophthalmitis was induced in rabbits by intracameraladministration of E.faecalis KOS1 at the end of cataract surgerywith IOL implantation (106 CFU/eye). E. faecalis strain, KOS1(clinical isolate from endophthalmitis case) were used. IntracameralGFLX 0.5% were administered at the end of surgery (immediatelypostinfection). Silicone IOLs were used for intracameral antibioticsgroup. D.D.IOLs, antibiotics-treated hydrogel lenses, were immersedin GFLX 0.5%. Those eyes were enucleated at 24 hr, 48 hr and72 hr postinfection. Bacterial population within those eyeswas examined. Aqueous concentrations for GFLX were detectedin both groups using by HPLC.
Tables showed the bacterial populations in eyes , and aqueousconcentrations for GFLX through 72 hr. Both intracameral GFLXgroup and D.D.IOL group performed significantly better thancontrol in the treatment of endophthalmitis (P<0.01). Therewere no differences between those 2 groups. Aqueous concentrationsin intracameral GFLX group were higher than those in D.D.IOLgroup at 4 hr and 8 hr after surgery. However, at 24 hr, therewere no differences between these 2 groups.
Intracameral GFLX 0.5% and D.D.IOL (adsorbed GFLX 0.5%) havesimilar efficacy in the treatment of E. faecalis endophthalmitisin rabbits.
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