May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Fundus Autofluorescence and Choroidal Melanocytic Tumors
Author Affiliations & Notes
  • D. Lavinsky
    Ophthalmology, Vision Institute UNIFESP, Sao Paulo, Brazil
  • R. Belfort Neto
    Ophthalmology, Vision Institute UNIFESP, Sao Paulo, Brazil
  • E. Navajas
    Ophthalmology, Vision Institute UNIFESP, Sao Paulo, Brazil
  • V. Torres
    Ophthalmology, Vision Institute UNIFESP, Sao Paulo, Brazil
  • M. C. Martins
    Ophthalmology, Vision Institute UNIFESP, Sao Paulo, Brazil
  • R. Belfort, Jr.
    Ophthalmology, Vision Institute UNIFESP, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships D. Lavinsky, None; R. Belfort Neto, None; E. Navajas, None; V. Torres, None; M.C. Martins, None; R. Belfort, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 4786. doi:
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    • Get Citation

      D. Lavinsky, R. Belfort Neto, E. Navajas, V. Torres, M. C. Martins, R. Belfort, Jr.; Fundus Autofluorescence and Choroidal Melanocytic Tumors. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4786.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To describe autofluorescence patterns of choroidal melanocytic lesions using the Heidelberg Retinal Angiograph 2 (HRA2).

Methods:: Thirteen patients with choroidal melanocytic lesions in the ocular fundus were submitted to comprehensive ophthalmologic examination, autofluorescence, fluorescein angiography (FA), ocular ultrasound and optical coherence tomography (OCT). Pathological evaluation using Sudan Black B, PAS, Ziehl Neelsen and fluorescence microscopy was conducted in one enucleated eye with large choroidal melanoma

Results:: Ten patients had diagnosis of choroidal naevi and three had malignant choroidal melanoma. Choroidal naevi did not show any characteristic autofluorescence pattern, although secondary retina pigmented epithelium (RPE) changes like drusen and pigment epithelium detachment appeared mildly hyperautofluorescent. The patients with malignant choroidal melanomas presented with orange pigmentation and intense confluent hyperautofluorescent signal over the lesion. Pathological studies of the large malignant melanoma revealed lipofuscin underlying the RPE and within the tumor and fluorescence microscopy showed hyperfluorescent deposits throughout the lesion.

Conclusions:: Autofluorescence may be a useful non-invasive tool to assess the presence of lipofucsin in pigmented choroidal lesions which may contribute to the diagnosis and differentiation of malignant lesions.

Keywords: tumors • melanoma • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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