May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Latanoprost versus 0.5% Timolol After Phacoemulsification and Intraocular Lens Implantation in Patients With Primary Open-Angel Glaucoma
Author Affiliations & Notes
  • A. Varavka
    Sankt-Petersburg afffiliate, S N Fyodorov''s Eye Microsurgery Complex, Sankt-Petersburg, Russian Federation
  • S. Shukhaev
    Sankt-Petersburg afffiliate, S N Fyodorov''s Eye Microsurgery Complex, Sankt-Petersburg, Russian Federation
  • Footnotes
    Commercial Relationships A. Varavka, None; S. Shukhaev, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 4823. doi:
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      A. Varavka, S. Shukhaev; Latanoprost versus 0.5% Timolol After Phacoemulsification and Intraocular Lens Implantation in Patients With Primary Open-Angel Glaucoma. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4823.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To evaluate the efficacy of Latanoprost and Timolol in early post-operative period after phacoemulsification and posterior chamber intraocular lens (IOL) implantation in patients with primary open-angel glaucoma (POAG).

Methods:: This prospective randomized double-masked clinical study comprised 80 patients with unoperated POAG, who had uneventful phacoemulsification and IOL implantation surgery. Patients were randomly assigned to 1 of 2 groups: pre- and post-operative application of 0.5% Timolol (Group I) or Latanoprost 0.005% (Group II). Intraocular pressure (IOP) was measured (pneumatonometry) before and on first, seventh and fourteenth days after surgery. The anterior chamber was examined for the levels of cells and flare using slitlamp biomicroscopy.

Results:: Pre-operatively, Mean IOP (± Standard Deviation) was 20.0±0.63 mmHg in group I and 19.0±0.74 mmHg in group II. Two patients in group I had transient hypertension on the first day after surgery. In both groups, Mean IOP at all three post-operative measurements was below 22.0 mmHg. However, on the seventh day, Mean IOP (± Standard Deviation) in group II (17.68±0.3 mmHg) was lower than in group I (21.18±0.53 mmHg). This difference appeared statistically significant (p<0.05). Throughout the two-week postoperative observation, all patients in both groups showed presence of slight inflammation in the anterior chamber, resolved within few days.

Conclusions:: In patient with unoperated POAG in early postoperative period after phacoemulsification and IOL implantation, Latanoprost is as safe as Timolol. Latanoprost exerts more pronounced hypotensive effect than Timolol regardless surgery-associated inflammatory events in the anterior chamber.

Clinical Trial:: www.clinicaltrials.gov 203675

Keywords: clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • eicosanoids • outflow: ciliary muscle 
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