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N. Unoki, K. Nishijima, A. Sakamoto, M. Kita, D. Watanabe, M. Hangai, T. Kimura, N. Kawagoe, M. Ohta, N. Yoshimura; Retinal Sensitivity Loss and Structural Disturbance in Capillary Non-Perfusion Area of Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5014.
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To assess light sensitivity and retinal structure of capillary non-perfusion areas in diabetic retinopathy.
Twenty eyes of 17 consecutive patients with capillary non-perfusion areas from severe non-proliferative and proliferative diabetic retinopathy underwent fundus-related microperimetry. Non-perfusion areas of diabetic retinas were imaged with a Fourier-domain high-resolution optical coherence tomography (FD-OCT).
In 20 of 20 diabetic eyes (100%), areas of capillary non-perfusion detected by fluorescein angiography were associated with areas of the loss of retinal sensitivity. At para-areas of capillary non-perfusion, the retinal sensitivities tended to be reduced. The images demonstrated with an FD-OCT suggested the structural disturbance of inner retina in capillary non-perfusion area.
Areas of capillary non-perfusion from severe non-proliferative and proliferative diabetic retinopathy has disturbed retinal structure, which may lead to sensitivity loss.
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