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P. Sasso, A. Scupola, S. Traina, B. Falsini, E. Balestrazzi; Functional Outcomes of Sequential Intravitreal Triamcinolone Acetonide/Grid Photocolagulation versus Grid Photocoagulation for Diabetic Macular Edema: A Short-Term Study Including Electrophysiology. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5034.
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To evaluate the potential benefits in functional/structural outcomes of sequential intravitreal Triamcinolone Acetonide (IVTA)/grid photocoagulation (GP) for diabetic macular edema (DME).
Fourteen insulin-dependent diabetic patients were randomly assigned to one of the following treatments. 1. IVTA followed after 4 weeks by a standard GP (n = 7). 2. Standard GP (n =7). For each patient, EDTRS acuity, microperimetry (Nikon MP1), focal ERGs and macular structure by OCT3, were measured in a blinded fashion at baseline and 3 months post-treatment.
At 3 months, EDTRS acuity improved (p < 0.05) in both groups compared to baseline values (average increase 14 and 15 letters, respectively). In group 1, but not in group 2 patients, FERG amplitude and MP1 sensitivity improved (p < 0.05) compared to baseline values. Macular thickness decreased (p < 0.01) from baseline in both groups (on average by 340 and 220 microns, respectively, between-group difference, p: ns).
Sequential IVTA/GP for DME may provide some benefits as revelaed by macular cone functional assays, suggesting an anti-flogistic protective role of IVTA on neuro-retinal neurons.
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