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I. Zundane, R. Adam, T. Rodallec, J. Nordmann; Visual Comfort of Armd Patients Proportional to Retinal Layer Quantitative Thickness and Photoreceptor Layer Loss. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5107.
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to evaluate visual comfort of ARMD patients previous and after PDT and Avastin treatment.
10 patients after PDT, 10 patients after PDT and IVT corticoid injection and 10 patients after PDT and Avastin IVT injection, 10 patients with only Avastin injection were evaluated by ETDRS and contrast sensitivity test, fluorescein angiography and OCT 1 month after treatment. Regarding OCT central 6 mm photoreceptor layer loss was graded between 1 and 4 (1.-75% loss, 2.-50% loss, 3.-25% loss, 4.-less than 25% loss). Retinal layer quantitative loss was similarly graded between 1 and 4. Free spaces of intraretinal liquid were excluded. All patients were admitted to the first session of each group of the treatment. No retreatments were included.
visual comfort was slightly better in only Avastin and PDT with corticoid IVT injection p=0.02. Group after PDT with later Avastin injection and only PDT group showed lower visual comfort rate p=0.02. Probably PDT with later Avastin injection was less satisfied due to incomplete result after PDT that needed to be adjusted by Avastin IVT injection.
final subjective result is not only dependant on successful neovascular membrane treatment but also on preserved retinal layer and photoreceptor existence.
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