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J. A. Elledge, M. K. W. Webster, B. A. Blodi, R. P. Danis, Genentech Study Group; Serous Sensory Retinal Detachment as Measured by Photography and OCT in Neovascular AMD. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5121.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the detection and quantification of serous sensory retinal detachment (SSRD) observed by stereoscopic film color photographs and Optical Coherence Tomography (OCT) in eyes with neovascular age-related macular degeneration (AMD).
184 subjects with neovascular AMD were enrolled in the Genentech PIER study. Stereo color images and Zeiss Stratus OCT scans were performed on the study eyes prior to treatment and at month 12. Graders masked to treatment group reported the presence/absence of SSRD and retinal thickness from OCT scans and independently graded the presence and area of SSRD from the photographs. The presence of SSRD was compared.
Of evaluable baseline OCT scans, 49.6% had definite SSRD. In contrast, 79.3% of photographs were graded as demonstrating SSRD. At the 12 month visit, SSRD was graded as definitely present in 12.6% of OCT submissions and in 44.7% of photographs. Review of the discrepancies disclosed that in many eyes with apparent SSRD from photographs, the OCT revealed the retinal elevation was due to intraretinal edema or a combination of SSRD and retinal edema. While the area of combined edema and SSRD could be estimated from the photographs, the quantitative information regarding edema and subretinal fluid derived from the OCT grading was limited to center point measurements, with qualitative assessment of morphology elsewhere.
The appearance of SSRD in color photographs of eyes with neovascular AMD includes both subretinal and intraretinal fluid, as disclosed by comparison with OCT scans. OCT and stereoscopic photography provide complimentary information regarding signs of exudation in neovascular AMD.
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