May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Anti-Galectin-1 Antibodies in Patients With Pars Planitis
Author Affiliations & Notes
  • J. D. Luna Pinto
    Ophthalmology, Centro Privado de Ojos Romagosa-Fundacion VER, Cordoba, Argentina
  • J. C. Muiño
    Immunology, División Medicina III, Facultad de Ciencias, Universidad Nacional de Córdoba, Argentina
  • M. Romero
    Inmunology, Inmunopatología LIIDO, Cordoba, Argentina
  • M. Ferrero
    Inmunology, Laboratorio of Inmunopatología LIIDO, Cordoba, Argentina
  • G. Ravinovich
    Inmunopathology, Centro Privado de Ojos Romagosa-Fundacion VE
  • C. P. Juarez
    Ophthalmology, Centro Privado de Ojos Romagosa-Fundacion VER, Cordoba, Argentina
  • Footnotes
    Commercial Relationships J.D. Luna Pinto, None; J.C. Muiño, None; M. Romero, None; M. Ferrero, None; G. Ravinovich, None; C.P. Juarez, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 5186. doi:
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    • Get Citation

      J. D. Luna Pinto, J. C. Muiño, M. Romero, M. Ferrero, G. Ravinovich, C. P. Juarez; Anti-Galectin-1 Antibodies in Patients With Pars Planitis. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5186.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: Galectin - 1 (Gal -1), an endogenous galectin play a critical role in regulation of the immune response. We have previously demonstrated the presence of anti-gal-1 antibodies in patients with uveitis (ARVO, 2006). We know evaluate the presence of these auto-antibodies in patients with pars planitis.

Methods:: 17 patients with clinically diagnosed pars planitis, has been prospectively followed, from our uveitis clinic over the past 5 years, for the presence of specific IgG, IgA and IgE anti-gal-1 antibodies, by ELISA and compared with healthy control subjects (n: 14). The patients were classified according to clinical criteria and to the response to treatment in good (n: 13) and poor (n: 3) prognosis.

Results:: IgG and IgE anti Gal-1 only, or overlapped were increased in sera from patients with Pars Planitis and bad prognosis (n: 3) and the presence of specific IgA to Gal - 1 only (n: 1) or overlapped with IgG and IgE anti Gal - 1 (n: 12) presented good evolution (n: 13) (p<0.001). One case with moderate vision impairment did have IgG, IgA, IgE anti Gal - 1.

Conclusions:: The results presented here suggest the importance of specific IgG and IgE anti Gal - 1 in Pars Planitis with poor prognosis, as well as the presence of IgA anti Gal - 1 associated with good prognosis.

Keywords: immunomodulation/immunoregulation • autoimmune disease • immune tolerance/privilege 
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