Purchase this article with an account.
A. A. Yucel, K. Suner, B. Kaderli, E. Erdogan, H. Saricaoglu, K. Dilek; Retinal Vascular Reactivity to Physiologic Stimuli in Patients With Behçet's Disease: The Bifurcations. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5190.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To investigate kinetic characteristics of retinal vessel bifurcations (RVB) in patients with Behçets Disease (BD).
We examined one angle ( ω ) of each bifurcation from the right eyes of 6 non-ocular BD patients (age: 19-36 mean:29.66 yrs) with 11 RVB (5 arterial, 6 venous) compared to 6 healty volunteers (age: 21-27 mean:25.4yrs.) with10 RVB (6 art., 4 ven.). All were non-smoker and normotensive. We applied to right hands first hot (40° C), than cold water (4° C) and resting for 45 minutes. Red-free images of the fundus were taken before and after 3 phases and registered digitally with a fundus camera. RVB selection: 1- Visible vessel in all phases 2-Easily observable pattern of the camera flash reflex on the vessel 3- Diameter of the main vessel greater than 20 pixels.To measure the ω angle: 1) Edge detection and image sharpening 2) Follow the flash reflex line of the magnified daughter vessel (DV) 3) Draw a small line (appr. one and half DV diameter distance) at the junction site to main vessel, very close and parallel to the midline of the reflex for each DV. 4) Extend the line. 5) The same for the other DV. 6) Measure the angle created between 2 vessels. 7) Repeat the measurement for 5 times.
After eliminating the highest and lowest angle values of the 5 measurements for each (BA) we had a mean value of the 3 remaining. Hot application had dual effects on both arterial BAs of the BD patients and the control group(CG) compared to basic values: augmentation (AUG) and diminution (DIM) of the BAs in the same groups. But the DIM rates in BD patients were remarkably high: 7.78-10.39% (CG: 0.98-3.09%). Cold application created mainly AUG of arterial BA rates (5 of 6 patients: 1,13-9,17%) for the CG while BD patients showed mainly a diminution of art.BA rates ( 5 of 6 patients: 1,41-14,6%). The rest period affected both arterial groups similarly but AUG of BAs for BD was notably low. Application of hot showed no difference on the venous BA of BD patients and the CG. But with cold application all venous BD bifurcation angles demonstrated important diminution rates (2.9 to 26.69%), while CG had contradictory angle variation rates. After the rest venous BAs showed mainly low DIM rates for BD patients (5 of 6) and CG dual but elevated results.
Retinal vessel bifurcations in patients with so called non-ocular BD seem to react differently to physiologic stimuli; this is probably the sign of the still present ocular involvement.This study supports our previous findings ( ARVO 2005 #5096).
This PDF is available to Subscribers Only