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M. J. Hove, D. J. Spalton, E. Gavin, F. Bremner; The Preliminary Results of a Case Control Study Using Infrared Video Pupillographic Techniques to Determine What Effect Tamulosin Has on Physiological Pupil Parameters. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5537.
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To report the preliminary results of a case control study todetermine what effect tamulosin has on physiological pupil parameters.
16 patients already taking tamulosin were recruited from a urologyclinic. They were compared to 16 healthy controls who had nevertaken tamulosin. Pupil evaluation was by infra-red pupillographictechniques. Pupil diameters in the light and dark, and thenat 15, 30, 60 and 120 minutes after instillation of 10µlof 10% phenylephrine or 10µl of 10% phenylephrine and10µl of 1% cyclopentolate. The two different preparationswere randomised to each eye. The time for 75% recovery of thepupil size following presentation of a standard light stimulus(T3/4) was calculated.
The cohort on tamulosinhad longer T3/4 times, but dilated less in response phenylephrine(due to the alpha-adrenoceptor antagonist effect of tamulosin)as the healthy controls. We then compared the individual T3/4in this cohort to the normal database collected by the Nationalhospital for Neurology and Neurosurgery to see if all the patientson tamulosin had abnormal T3/4 times.Tamulosin cohort (sub-groupanalysis)
50% of patients who were on tamulosin had abnormal T3/4 times.These patients had also been on tamulosin for longer indicatingthat the effect of tamulosin on pupillary reactions seems tobe related to duration of use. The patients on tamulosin withnormal T3/4 were similar to the healthy controls. Further workis underway to see if abnormal T3/4 is correlated to the diagnosisof IFIS.
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