Purchase this article with an account.
D. Doro, P. Cimatti, P. Paolucci; Bimatoprost Every 24 versus 48 Hours in Eyes With Ocular Hypertension and/or Primary Open Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5570.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Intraocular pressure (IOP) lowering effect of daily administration of bimatoprost has been extensively studied, however ocular side effects such as conjunctival hyperemia , burning, eyelash lengthening and periocular pigmentation may affect compliance or cause discontinuation of the drug. The aim of this study is to evaluate the efficacy and side effects of bimatoprost administration every 24 versus 48 hours.
Baseline IOP diurnal curve at 9, 13, and 16 h was recorded in 20 eyes of ten caucasian patients with a mean age of 64 (range 56-75 ) years and newly diagnosed ocular hypertension or primary open angle glaucoma. All eyes have been treated for four weeks every 24 hours with bimatoprost at 10 pm; diurnal curve was recorded at week 1 and 4. Then the same eyes were given bimatoprost for four weeks every 48 hours at 10 pm and again diurnal curve was recorded at week 1 and 4 the second day after bimatoprost.
Baseline IOP decreased from 25.4+/- 2.8 ( range 22 - 32 ) to 17.8 +/- 1.4 (range 16-20 ) mmHg after daily bimatoprost (p< 0.001). With every other day bimatoprost IOP significantly increased to 19.0 +- 1.4 (range 17-22) mmHg as compared with daily bimatoprost. With both regimens of administration no statistical difference in IOP was noted at week 1 and 4, and IOP was slightly higher at 9 h as compared with the 16 h check. Of six eyes which developed ocular redness after daily bimatoprost, only two maintained mild conjunctival hyperemia after bimatoprost every 48 hours.
Our results based on a small series of patients with limited follow up indicate that mean IOP can be effectively reduced by bimatoprost both every 24 (30.0%) and 48 (25.2%) hours, and ocular redness can be reduced with bimatoprost every 48 hours as compared to standard daily administration. Long term pulsed administration of bimatoprost may affect compliance, on the other hand sporadic non adherence to the standard daily regimen would not lead to clinically relevant IOP fluctuations in patients with ocular hypertension or early primary open angle glaucoma.
This PDF is available to Subscribers Only