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L. P. Chong, R. Kerns, C. Yang, C. DeBoer, M. Humayun; Intraocular OCT Imaging With a Forward Imaging Needle Probe. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5664.
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To develop the technique and instrumentation to perform intraocular OCT
An intraocular OCT probe, 21 gauge, was developed and tested in enucleated porcine eyes. The OCT probe consists a fiber optical light pipe with a GRIN lens bonded at the distal end. The source is a 1.3nm laser. The opacified cornea and lens of porcine eyes were removed in order to visualize and hence place the OCT probe close to the retina and optic nerve. The OCT probe was passed through the vitreous towards the surface of the retina.
A-scan images which delineated the high reflective interfaces of the sensory retina, retinal vasculature and retina/choroid complex were achieved . Manual manipulation of the probe achieved limited B-scan images. These limited B-scan images were able to demonstrate sensory retinal detachment. Best results were obtained with the probe within 1 mm of the neurosensory retina.
A first generation prototype intraocular OCT probe was able to delineate important important histological features of the retina despite limited resolution. At this time only A-scan images can be obtained. Engineering challenges include incorporation of scanning into the small diameter probe to achieve B-scan images, further reduction of diameter and sealing to enable resterilization of probe. An intraocular OCT probe may be useful for the vitreous surgeon in identifying intraocular structures otherwise difficult to visualize with a microscope and may help improve intraocular outcomes.
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