May 2007
Volume 48, Issue 13
ARVO Annual Meeting Abstract  |   May 2007
Clinical Characteristics and Glial Changes After Radical Retinectomy for Severe Rhegmatogenous Retinal Detachment
Author Affiliations & Notes
  • K. Johansson
    Ophthalmology, Lund University, Malmoe, Sweden
  • F. Ghosh
    Ophthalmology, Lund University, Malmoe, Sweden
  • Footnotes
    Commercial Relationships K. Johansson, None; F. Ghosh, None.
  • Footnotes
    Support The Faculty of Medicine, University of Lund, The Swedish Research Council, The Princess Margaretas Foundation for blind Children, The Maggie Stephen Foundation
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 5715. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      K. Johansson, F. Ghosh; Clinical Characteristics and Glial Changes After Radical Retinectomy for Severe Rhegmatogenous Retinal Detachment. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5715.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose:: To investigate clinical features and histopathological changes after retinectomy for severe cases of rhegmatogenous retinal detachment (RRD).

Methods:: A retrospective study including 7 eyes from 7 patients with recurrent severe RRD. All eyes had previously undergone several surgical procedures for RRD. In 3 eyes, a limited retinectomy had been performed. The total duration of retinal detachment was 2-14 months (median 3). Visual acuity (VA) ranged from hand motion to 0,2 (median 0,02). All eyes displayed severe intraretinal proliferativ vitreoretinal retinopathy (PVR) with subsequent neuroretinal shortening. The surgery included a standard 3-port vitrectomy, peripheral retinectomy 120-240°, laser retinopexy and silicone oil tamponade. Lensectomy was performed at the same time on 4 out of 6 fakic eyes. In addition, a full-thickness neuroretinal specimen was obtained for histopathological examination including hematoxylin and eosin stainining as well as immunohistochemistry against glial fibrillary acidic protein (GFAP).

Results:: Silicon oil was removed in 5 eyes, and in all of these a complete retinal reattachment was achieved with a follow-up of 3-13 months. Reattacchment of the central part of retina was seen in 2 eyes although the periferal retina was still detached, and in these eyes a decision to leave the silikonoil was made. Visual acuity was improved or stabilized in 5 eyes. In the neuroretinal specimens, severe degenerative changes were seen. The retinal layers were thin with only a few rows of cells, and no inner or outer segments were found. A massive upregulation of GFAP was found in immunolabeled sections. In 5 eyes, a massive gliotic reaction with subretinal hypertrophy of the Müller cells was also seen.

Conclusions:: Radical retinectomy can be used to reattach the retina and preserve a certain degree of visual function in RRD eyes with severe intraretinal PVR. The degenerative and gliotic changes found confirms that long term RRD severely affects retina and its possibility of reattachment or function.

Keywords: retinal detachment • retina • vitreoretinal surgery 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.