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L. Wickham, D. G. Charteris; Intensive Anti-Inflammatory Therapy as an Adjuvant Treatment for Established Proliferative Vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5740.
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To determine the effect of intensive anti-inflammatory therapy as an adjuvant in the treatment of established proliferative vitreoretinopathy (PVR).
A consecutive case series of patients with grade C PVR were enrolled. All patients underwent vitrectomy and silicone oil injection with membrane peeling and retinectomy as required. Treatment consisted of pre-operative topical prednisolone acetate; per-operative intravitreal triamcinolone 4mg and sub-tenon injection of triamcinolone 40mg; post-operative topical prednisolone actetate and oral flurbiprofen 50mg.
13 patients (7 male and 6 female) were recruited. At least five clock hours of grade C PVR was present in all patients. 7 patients had previous surgery for rhegmatogenous retinal detachment prior to enrolment. In 11 of 13 patients (85%) the retina was successfully attached following surgery. In 1 patient the retina re-detached following removal of silicone oil and 1 patient developed a tractional retinal detachment under silicone oil. A post-operative rise in intraocular pressure was observed in 1 patient and was controlled with topical medication.
Intensive ant-inflammatory adjunctive therapy is a feasible and well tolerated treatment of established PVR. Further studies are now underway.
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