May 2007
Volume 48, Issue 13
ARVO Annual Meeting Abstract  |   May 2007
A Drug Delivery System and Intraocular Lens
Author Affiliations & Notes
  • S. Eperon
    Ocular Immunology, Jules Gonin Eye Hospital, Lausanne, Switzerland
  • L. Bossy-Nobs
    School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Switzerland
  • R. Gurny
    School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Switzerland
  • I. K. Petropoulos
    Ocular Immunology, Jules Gonin Eye Hospital, Lausanne, Switzerland
  • Y. Guex-Crosier
    Ocular Immunology, Jules Gonin Eye Hospital, Lausanne, Switzerland
  • Footnotes
    Commercial Relationships S. Eperon, UNITEC, Geneva, P; L. Bossy-Nobs, UNITEC, Geneva, P; R. Gurny, UNITEC, Geneva, P; I.K. Petropoulos, None; Y. Guex-Crosier, UNITEC, Geneva, P.
  • Footnotes
    Support Swiss National Science Foundation Grant 3200B0-105337
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 5784. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      S. Eperon, L. Bossy-Nobs, R. Gurny, I. K. Petropoulos, Y. Guex-Crosier; A Drug Delivery System and Intraocular Lens. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5784.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose:: Cataract surgery induces inflammation and may worsen preexisting ocular pathologies. High doses of steroids are often required via oral or injection route, implying risks and side-effects. To avoid them, we developed a biodegradable drug delivery system (DDS) associated to the artificial intraocular lens (IOL).

Methods:: DDS was prepared using poly(D,L-lactide-co-glycolide) (PLGA) with different Mw. DDS was loaded with triamcinolone acetonide (TA). Cataract surgery was performed on the right eye of pigmented rabbits and IOL associated with DDS was inserted. Four parameters were measured: i) the clinical score (sum of hyperemia, chemosis, corneal edema and discharge, each scored from 0 to 3), ii) the intraocular pressure, iii) the number of inflammatory cells in aqueous humor (AH) and iv) the protein concentration in AH .

Results:: The minidisk-like DDS weighed approximately 3 mg and contained around 1 mg of TA. In vitro release studies indicated that the higher the Mw of the DDS, the slower was the release of TA. Rabbits were implanted with IOL wearing i) no DDS (n=4), ii) unloaded DDS (n=4), iii) one loaded DDS (n=7), iv) two loaded DDSs (n=6). IOL insertion with unloaded DDS did not induce more inflammation than IOL without DDS, indicating a good ocular biocompatibility. One loaded DDS (Mw=48’000 Da) could significantly reduce ocular inflammation induced by surgery. Inhibition of protein migration reached 58%, 76% and 61% at 7, 14 and 21 days after surgery, respectively. Two loaded DDS could inhibit inflammation by 94% at 7 days, 97% at 14 days and 90% at 21 days after surgery.

Conclusions:: The combination of IOL with DDS made of PLGA and loaded with TA could significantly inhibit post-operative inflammation. This system, loaded with TA or other drugs, may be useful to treat severe pathologies such as exudative age-related macular degeneration (AMD), proliferative vitreoretinopathy and diabetic macular edema.

Keywords: inflammation • drug toxicity/drug effects • treatment outcomes of cataract surgery 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.